Gelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBruschi, M. L.
dc.creatorCardoso, MLC
dc.creatorLucchesi, M. B.
dc.creatorGremiao, MPD
dc.date2014-05-20T13:24:22Z
dc.date2016-10-25T16:45:04Z
dc.date2014-05-20T13:24:22Z
dc.date2016-10-25T16:45:04Z
dc.date2003-10-02
dc.date.accessioned2017-04-05T19:59:50Z
dc.date.available2017-04-05T19:59:50Z
dc.identifierInternational Journal of Pharmaceutics. Amsterdam: Elsevier B.V., v. 264, n. 1-2, p. 45-55, 2003.
dc.identifier0378-5173
dc.identifierhttp://hdl.handle.net/11449/7526
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7526
dc.identifier10.1016/S0378-5173(03)00386-7
dc.identifierWOS:000185658700005
dc.identifierhttp://dx.doi.org/10.1016/S0378-5173(03)00386-7
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856145
dc.descriptionGelatin microparticles containing propolis extractive solution (PES) were prepared by spray-drying technique. The optimization of the spray-drying operating conditions and the proportions of gelatin and mannitol were investigated. Regular particle morphology was obtained when mannitol was used, whereas mannitol absence produced a substantial number of coalesced and agglomerated microparticles. Microparticles had a mean diameter of 2.70 mum without mannitol and 2.50 mum with mannitol. The entrapment efficiency for propolis of the microparticles was upto 41 % without mannitol and 39% with mannitol. The microencapsulation by spray-drying technique maintained the activity of propolis against Staphylococcus aureus. These gelatin microparticles containing propolis would be useful for developing intermediary or eventual propolis dosage form without the PES' strong and unpleasant taste, aromatic odour, and presence of ethanol. (C) 2003 Elsevier B.V. All rights reserved.
dc.languageeng
dc.publisherElsevier B.V.
dc.relationInternational Journal of Pharmaceutics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectpropolis
dc.subjectgelatin
dc.subjectspray-drying
dc.subjectmicroparticle characterization
dc.subjectoptimization
dc.titleGelatin microparticles containing propolis obtained by spray-drying technique: preparation and characterization
dc.typeOtro


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