Phenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activity

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCalvo, Tamara Regina
dc.creatorDemarco, Diego
dc.creatorSantos, Fabio V.
dc.creatorMoraes, Helen P.
dc.creatorBauab, Tais M.
dc.creatorVaranda, Eliana Aparecida
dc.creatorColus, Ilce M. S.
dc.creatorVilegas, Wagner
dc.date2014-05-20T13:24:15Z
dc.date2016-10-25T16:44:59Z
dc.date2014-05-20T13:24:15Z
dc.date2016-10-25T16:44:59Z
dc.date2010-08-01
dc.date.accessioned2017-04-05T19:59:33Z
dc.date.available2017-04-05T19:59:33Z
dc.identifierNatural Product Communications. Westerville: Natural Products Inc, v. 5, n. 8, p. 1225-1232, 2010.
dc.identifier1934-578X
dc.identifierhttp://hdl.handle.net/11449/7470
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7470
dc.identifierWOS:000281074200016
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/20839624
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856107
dc.descriptionPhenolic compounds are produced by secretory idioblasts and hypodermis, and by specialized cells of the epidermis and chlorenchyma of leaves of Alchornea triplinervia. Phytochemical investigation of these leaves led to the isolation of the known substances quercetin, quercetin-7-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-glucopyranoside, quercetin-3-O-beta-D-galactopyranoside, quercetin-3-O-alpha-L-arabinopyranoside, amentoflavone, brevifolin carboxylic acid, gallic acid, and methyl gallate from the methanolic extract, and stigmasterol, campesterol, sitosterol, lupeol, friedelan-3-ol, and friedelan-3-one from the chloroform extract. In studies of antibacterial activity and mutagenicity, the methanolic extract showed promising activity against Staphylococcus aureus (MIC=62.5 mu g/mL) and was slightly mutagenic in vitro and in vivo at the highest concentrations tested (1335 mg/kg b.w.).
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherNatural Products Inc
dc.relationNatural Product Communications
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlchornea triplinervia
dc.subjectflavonoids
dc.subjectantibacterial activity
dc.subjectmutagenicity
dc.subjectsecretory structures
dc.titlePhenolic compounds in leaves of Alchornea triplinervia: anatomical localization, mutagenicity, and antibacterial activity
dc.typeOtro


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