Synthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorSantos, Jean L.
dc.creatorYamasaki, Paulo R.
dc.creatorChin, Chung Man
dc.creatorTakashi, Celio H.
dc.creatorPavan, Fernando Rogério
dc.creatorLeite, Clarice Queico Fujimura
dc.date2014-05-20T13:24:14Z
dc.date2016-10-25T16:44:58Z
dc.date2014-05-20T13:24:14Z
dc.date2016-10-25T16:44:58Z
dc.date2009-06-01
dc.date.accessioned2017-04-05T19:59:26Z
dc.date.available2017-04-05T19:59:26Z
dc.identifierBioorganic & Medicinal Chemistry. Oxford: Pergamon-Elsevier B.V. Ltd, v. 17, n. 11, p. 3795-3799, 2009.
dc.identifier0968-0896
dc.identifierhttp://hdl.handle.net/11449/7458
dc.identifierhttp://acervodigital.unesp.br/handle/11449/7458
dc.identifier10.1016/j.bmc.2009.04.042
dc.identifierWOS:000266117400007
dc.identifierhttp://dx.doi.org/10.1016/j.bmc.2009.04.042
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856095
dc.descriptionNew phthalimide derivatives were easily prepared through condensation of phthalic anhydride and selected amines with variable yields (70-90%). All compounds (3a-l) were evaluated against Mycobacterium tuberculosis H(37)Rv using Alamar Blue susceptibility. The compounds 3c, 3i, and 3l have the minimum inhibitory concentrations (MICs) of 3.9, 7.8, and 5.0 mu/mL, respectively, and could be considered new lead compounds in the treatment of tuberculosis and multi-drug resistant tuberculosis. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherPergamon-Elsevier B.V. Ltd
dc.relationBioorganic & Medicinal Chemistry
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPhthalimide derivatives
dc.subjectAntimycobacterial
dc.subjectAntitubercular activity
dc.subjectCytotoxicity
dc.titleSynthesis and in vitro anti Mycobacterium tuberculosis activity of a series of phthalimide derivatives
dc.typeOtro


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