Antimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune system

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorCarli, Camila B. de A.
dc.creatorQuilles, Marcela B.
dc.creatorMaia, Daniele C. G.
dc.creatorLopes, Flavia C. M.
dc.creatorSantos, Rubens
dc.creatorPavan, Fernando R.
dc.creatorFujimura Leite, Clarice Q.
dc.creatorCalvo, Tamara Regina
dc.creatorVilegas, Wagner
dc.creatorCarlos, Iracilda Z.
dc.date2014-05-20T13:23:53Z
dc.date2014-05-20T13:23:53Z
dc.date2010-08-01
dc.date.accessioned2017-04-05T19:58:45Z
dc.date.available2017-04-05T19:58:45Z
dc.identifierPharmaceutical Biology. Philadelphia: Taylor & Francis Inc, v. 48, n. 8, p. 878-882, 2010.
dc.identifier1388-0209
dc.identifierhttp://hdl.handle.net/11449/7285
dc.identifier10.3109/13880200903303471
dc.identifierWOS:000281304800006
dc.identifier0000-0003-3032-2556
dc.identifierhttp://dx.doi.org/10.3109/13880200903303471
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/856004
dc.descriptionMycobacterium tuberculosis is responsible for over 8 million cases of tuberculosis (TB) annually. Natural products may play important roles in the chemotherapy of TB. The antimycobacterial activity and the innate immune response of methanol (METH) and dichloromethane (DCM) extracts of Indigofera suffruticosa Miller (Fabaceae) were evaluated. We observed that the minimum inhibitory concentrations (MICs) for METH and DCM extracts were 125 and 1000 mu g/mL, respectively. However, they were able to induce the innate immune response through the production of high levels of NO and TNF-alpha (p < 0.001) by peritoneal exudate cells (PECs). These results suggest that I. suffruticosa extracts may have an important immunological role in the control of TB once macrophage activity is induced by them.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageeng
dc.publisherTaylor & Francis Inc
dc.relationPharmaceutical Biology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntimycobacterial activity
dc.subjectIndigofera suffruticosa
dc.subjectinnate immune response
dc.titleAntimycobacterial activity of Indigofera suffruticosa with activation potential of the innate immune system
dc.typeOtro


Este ítem pertenece a la siguiente institución