A Toll-receptor map underlies structural brain plasticity

dc.creatorLi, Guiyi
dc.creatorForero, Manuel G.
dc.creatorWentzell, Jill S.
dc.creatorDurmus, Ilgim
dc.creatorWolf, Reinhard
dc.creatorAnthoney, Niki C.
dc.creatorParker, Mieczyslaw
dc.creatorJiang, Ruiying
dc.creatorHasenauer, Jacob
dc.creatorStrausfeld, Nicholas James
dc.creatorHeisenberg, Martin
dc.creatorHidalgo, Alicia
dc.date2020-09-10T21:16:24Z
dc.date2020-09-10T21:16:24Z
dc.date2020-02-18
dc.date.accessioned2023-08-31T19:24:41Z
dc.date.available2023-08-31T19:24:41Z
dc.identifierLi G, Forero MG, Wentzell JS, et al. A Toll-receptor map underlies structural brain plasticity. Elife. 2020;9:e52743. Published 2020 Feb 18. doi:10.7554/eLife.52743
dc.identifier2050-084X
dc.identifierhttps://pubmed.ncbi.nlm.nih.gov/32066523/
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8558057
dc.descriptionExperience alters brain structure, but the underlying mechanism remained unknown. Structural plasticity reveals that brain function is encoded in generative changes to cells that compete with destructive processes driving neurodegeneration. At an adult critical period, experience increases fiber number and brain size in Drosophila. Here, we asked if Toll receptors are involved. Tolls demarcate a map of brain anatomical domains. Focusing on Toll-2, loss of function caused apoptosis, neurite atrophy and impaired behaviour. Toll-2 gain of function and neuronal activity at the critical period increased cell number. Toll-2 induced cycling of adult progenitor cells via a novel pathway, that antagonized MyD88-dependent quiescence, and engaged Weckle and Yorkie downstream. Constant knock-down of multiple Tolls synergistically reduced brain size. Conditional over-expression of Toll-2 and wek at the adult critical period increased brain size. Through their topographic distribution, Toll receptors regulate neuronal number and brain size, modulating structural plasticity in the adult brain.
dc.descriptionUniversidad de Ibagu?
dc.languageen
dc.publishereLife
dc.subjectD. melanogaster
dc.subjectDrosophila
dc.subjectMyD88
dc.subjectToll
dc.subjectYorkie
dc.subjectAdult progenitor cells
dc.subjectAdult neurogenesis
dc.subjectBrain
dc.subjectCritical period
dc.subjectNeurodegeneration
dc.subjectNeuron
dc.subjectNeuronal activity
dc.subjectNeuroscience
dc.subjectQuiescence
dc.subjectTructural plasticity
dc.subjectWek
dc.titleA Toll-receptor map underlies structural brain plasticity
dc.typeArticle


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