The influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis

dc.contributorUniversidade Estadual Paulista (UNESP)
dc.creatorBarboza-Filho, Carlos G.
dc.creatorCabrera, Flavio C.
dc.creatorDos Santos, Renivaldo J.
dc.creatorDe Saja Saez, Jose Antonio
dc.creatorJob, Aldo Eloizo
dc.date2014-05-20T13:23:02Z
dc.date2016-10-25T16:44:06Z
dc.date2014-05-20T13:23:02Z
dc.date2016-10-25T16:44:06Z
dc.date2012-02-01
dc.date.accessioned2017-04-05T19:56:15Z
dc.date.available2017-04-05T19:56:15Z
dc.identifierExperimental Parasitology. San Diego: Academic Press Inc. Elsevier B.V., v. 130, n. 2, p. 152-158, 2012.
dc.identifier0014-4894
dc.identifierhttp://hdl.handle.net/11449/6871
dc.identifierhttp://acervodigital.unesp.br/handle/11449/6871
dc.identifier10.1016/j.exppara.2011.10.015
dc.identifierWOS:000300129500011
dc.identifierhttp://dx.doi.org/10.1016/j.exppara.2011.10.015
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/855685
dc.descriptionThe development of nanotechnology has generated new means of disease diagnosis and treatment. Infectious diseases, including leishmaniasis, malaria, etc., have benefited from the advent of new nanomaterials and/or nanodevices capable of detecting specific antigens and antibodies with high specificity and low cost. In this paper, we present an investigation on a single-celled protozoan Leishmaniasis parasite, a disease considered of standard infectivity, given the high degree of immunological specificity. Natural rubber (NR) membranes incorporating gold nanoparticles (GNPs) were placed in the culture medium and the physiological behavior of Leishmania brasiliensis promastigotes was evaluated. The natural rubber membranes containing GNPs decreased the population growth rate, showing a lower index of living promastigotes (attached to the membrane surface) depending on the amount of nanoparticles deposited in the membrane surface. Such membranes may be used to develop a flexible band-aid for skin lesions from degenerative infection state, inhibiting the population growth of parasites in the lesions. In addition, natural rubber membranes would also stimulate angiogenesis in damaged tissues. (C) 2011 Elsevier B.V. All rights reserved.
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageeng
dc.publisherAcademic Press Inc. Elsevier B.V.
dc.relationExperimental Parasitology
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGold nanoparticles
dc.subjectNatural rubber
dc.subjectLeishmania brasiliensis
dc.titleThe influence of natural rubber/Au nanoparticle membranes on the physiology of Leishmania brasiliensis
dc.typeOtro


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