Synthesis, crystal structure, catalytic and anti-Trypanosoma cruzi activity of a new chromium(III) complex containing bis(3,5-dimethylpyrazol-1-yl)methane

dc.creatorHurtado, John
dc.creatorIbarra, Laura
dc.creatorYepes, David
dc.creatorGarc?a-Huertas, Paola
dc.creatorMac?as, Mario
dc.creatorTriana-Chavez, Omar
dc.creatorNagles, Edgar
dc.creatorSuescun, Leopoldo
dc.creatorMu?oz-Castro, Alvaro
dc.date2019-03-04T16:48:01Z
dc.date2019-03-04T16:48:01Z
dc.date2017-06-01
dc.date.accessioned2023-08-31T19:12:50Z
dc.date.available2023-08-31T19:12:50Z
dc.identifierHurtado, J., Ibarra, L., Yepes, D., Garc?a-Huertas, P., Mac?as, M. A., Triana-Chavez, O., ? Mu?oz-Castro, A. (2017). Synthesis, crystal structure, catalytic and anti-Trypanosoma cruzi activity of a new chromium(III) complex containing bis(3,5-dimethylpyrazol-1-yl)methane. Journal of Molecular Structure, 1146, 365?372.
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0022286017307901
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8556368
dc.descriptionThe reaction of CrCl36H2O with the ligand bis(3,5-dimethylpyrazol-1-yl)methane (L) yielded the cationic complex [(Cr(L)(H2O)2Cl2]+, which crystallized as the chloride trihydrate [(Cr(L)(H2O)2Cl2]Cl?3H2O. The chromium complex was characterized by elemental analysis, electrical conductivity, Infrared and Ultraviolet/Visible spectroscopy. The crystal structure determination using single-crystal X-ray diffraction showed a chromium center in a distorted octahedral coordination sphere. In the crystal, the packing was directed by OH?(O,Cl) hydrogen bonds and weak CH?O interactions to build a monoclinic P21/c supramolecular structure. The complex showed excellent properties as an initiator for the ring opening polymerization of ?-caprolactone (CL) under solvent-free conditions. The obtained polymer showed high crystallinity (89.9%) and a decomposition temperature above 475 ?C. In addition, the new complex was evaluated against epimastigotes from Trypanosoma cruzi (T. cruzi) strains. The results indicated that this complex has a high activity against this parasite with a minimum inhibitory concentration 50 (MIC50) of 1.08 ?g/mL. Interestingly, this compound showed little effect on erythrocytes, indicating that it is not cytotoxic. These results provide interesting contributions to the design of metal complexes by using simple and accessible ligands with activity against T. cruzi and with potential applications in the polymerization of CL.
dc.languageen
dc.publisherJournal of Molecular Structure
dc.subjectChromium complex
dc.subjectCrystal structure
dc.subjectRing opening polymerization
dc.subject?-caprolactone
dc.subjectTrypanosoma cruzi
dc.titleSynthesis, crystal structure, catalytic and anti-Trypanosoma cruzi activity of a new chromium(III) complex containing bis(3,5-dimethylpyrazol-1-yl)methane
dc.typeArticle


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