Evaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments

dc.creatorPardini, Francisco
dc.creatorFaccia, Paula
dc.creatorAmalvy, Javier
dc.date2019-02-02T21:55:29Z
dc.date2019-02-02T21:55:29Z
dc.date2015
dc.date.accessioned2023-08-31T14:03:49Z
dc.date.available2023-08-31T14:03:49Z
dc.identifierJournal of Drug Delivery Science and Technology
dc.identifierhttp://hdl.handle.net/20.500.12272/3409
dc.identifier10.1016/j.jddst.2015.10.016
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8545739
dc.descriptionSmart sensitive polymers have been used to improve processes in drug delivery. In this article, we evaluate the behavior of polyurethane/N,N-diethylaminoethyl methacrylate hybrids (PU/DEA) as pH- responsive polymers potentially useful for drug delivery systems development, using Rhodamine 6G (Rh6G) as a model drug. A detailed pH responsive characterization was performed by swelling studies and scanning electron microscopy (SEM). Two drug loading methods on drug release-immersion and direct loading were evaluated. The interaction between Rh6G and the polymer matrix was studied by Fourier Transform Infrared (FTIR) spectroscopy and contact angle determination. The kinetic study of Rh6G release was performed at basic and acidic pH; the mechanism of drug delivery was analyzed using Ritger-Peppas' equation. We discuss about polymer's active sites and drug's distribution through the matrix in relation to both loading methods. Results showed a pH-responsive behavior and morphological changes when pH solution varied from 9.0 to 4.0. In the immersion loading method, results indicated a higher Rh6G molecule concentration at the surface as well as ionic interaction between the drug and polymer's carboxylic groups. Release studies confirmed the pH-sensitive hybrid systems' behavior and kinetic exponent values indicated different mechanism's transport types depending on loading method and polymer composition.
dc.descriptionFil: Pardini, Francisco. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA; Argentina
dc.descriptionFil: Paula A. Faccia, Paula. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET; Argentina

dc.descriptionFil: Amalvy, Javier. UNLP (Universidad Nacional de La Plata). INIFTA (Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas). CONICET. CIDEPINT (Centro de Investigación y Desarrollo en Tecnología de Pinturas) CONICET/CICPBA. UTN (Universidad Tecnológica Nacional). CITEMA (Centro de Investigación y Desarrollo en Ciencia y Tecnología de Materiales); Argentina
dc.descriptionPeer Reviewed
dc.formatapplication/pdf
dc.languageeng
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rightsAtribución (Attribution): En cualquier explotación de la obra autorizada por la licencia será necesario reconocer la autoría (obligatoria en todos los casos). No comercial (Non Commercial): La explotación de la obra queda limitada a usos no comerciales. Sin obras derivadas (No Derivate Works): La autorización para explotar la obra no incluye la posibilidad de crear una obra derivada (traducciones, adaptaciones, etc.).
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional
dc.subjectPolymeric hybrid materials, Polyurethanes, poly(N,N-diethylaminoethyl methacrylate), Stimuli-sensitive polymers, Drug delivery systems, Films
dc.titleEvaluation of pH-sensitive polyurethane 2-diethylaminoethyl methacrylate hybrids potentially useful for drug delivery developments
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeinfo:ar-repo/semantics/artículo


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