Antiprotozoal Effect of Baccharis spicata and B. punctulata Volatile Oils and Their Active Components Against Trypanosoma cruzi

dc.creatorFerretti, Matías D.
dc.creatorRodriguez, María Victoria
dc.creatorFerretti, Anabela
dc.creatorNocito, Isabel Cristina del Rosario
dc.creatorBettucci, Gabriel Roberto
dc.creatorSrebot, Maria Sol
dc.creatorLarghi, Enrique Leandro
dc.creatorMartínez, María Laura
dc.date2022-02
dc.date.accessioned2023-08-31T00:36:45Z
dc.date.available2023-08-31T00:36:45Z
dc.identifierhttp://hdl.handle.net/11336/204203
dc.identifierFerretti, Matías D.; Rodriguez, María Victoria; Ferretti, Anabela; Nocito, Isabel Cristina del Rosario; Bettucci, Gabriel Roberto; et al.; Antiprotozoal Effect of Baccharis spicata and B. punctulata Volatile Oils and Their Active Components Against Trypanosoma cruzi; Springer; Revista Brasileira de Farmacognosia; 32; 1; 2-2022; 133-138
dc.identifier1981-528X
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8543606
dc.descriptionIn the current study, the chemical composition of Baccharis spicata (Lam.) Baill. and B. punctulata DC., Asteraceae, aerial parts’ volatile oils were analysed. A higher proportion of monoterpenes than sesquiterpenes was detected in oils of inflorescence of both species. In contrast, a dominance of sesquiterpene components above the monoterpenes was found in the vegetative organs. β-Pinene, limonene, spathulenol and caryophyllene oxide were among the most abundant components along with (−)-alismol, only detected in B. punctulata and described for the first time in Baccharis oils. Storage at room temperature produced considerable changes in both oils’ composition, due to chemical transformation of terpenoids. Cytotoxic and trypanocidal activity of B. spicata and B. punctulata inflorescence volatile oils were evaluated. Bioactivity-guided fractionation yielded five active fractions for each species which effectively inhibited Trypanosoma cruzi epimastigote growth in a concentration-dependent manner (IC50 between 2.15 and 12.49 μg/ml). In order to compare the trypanocidal activity and the cytotoxicity of volatile oils for HepG2/C3A cells, the selectivity index was estimated. All samples showed to be more effective against parasites than human cells, with the selectivity index above 2.0. Among the fractions tested, samples enriched in alismol, spathulenol and caryophyllene oxide were the most active and selective against epimastigote forms. Graphical abstract: [Figure not available: see fulltext.]
dc.descriptionFil: Ferretti, Matías D.. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas; Argentina
dc.descriptionFil: Rodriguez, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas; Argentina
dc.descriptionFil: Ferretti, Anabela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario; Argentina. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Fisiológicas. Área Morfología; Argentina
dc.descriptionFil: Nocito, Isabel Cristina del Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
dc.descriptionFil: Bettucci, Gabriel Roberto. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Departamento de Ciencias Biológicas; Argentina
dc.descriptionFil: Srebot, Maria Sol. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
dc.descriptionFil: Larghi, Enrique Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
dc.descriptionFil: Martínez, María Laura. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas; Argentina
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dc.languageeng
dc.publisherSpringer
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s43450-021-00226-6
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1007/s43450-021-00226-6
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject(−)-ALISMOL
dc.subjectCARYOPHYLLENE OXIDE
dc.subjectCYTOTOXICITY
dc.subjectESSENTIAL OILS
dc.subjectSPATHULENOL
dc.subjectTRYPANOCIDAL ACTIVITY
dc.subjecthttps://purl.org/becyt/ford/1.4
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleAntiprotozoal Effect of Baccharis spicata and B. punctulata Volatile Oils and Their Active Components Against Trypanosoma cruzi
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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