The inflammatory response induced by Pseudomonas aeruginosa in macrophages enhances apoptotic cell removal

dc.creatorJager, Adriana Valeria
dc.creatorArias, Paula Alejandra
dc.creatorTribulatti, María Virginia
dc.creatorBrocco, Marcela Adriana
dc.creatorPepe, María Victoria
dc.creatorKierbel, Arlinet, Verónica
dc.date2021-01
dc.date.accessioned2023-08-31T00:24:34Z
dc.date.available2023-08-31T00:24:34Z
dc.identifierhttp://hdl.handle.net/11336/185000
dc.identifierJager, Adriana Valeria; Arias, Paula Alejandra; Tribulatti, María Virginia; Brocco, Marcela Adriana; Pepe, María Victoria; et al.; The inflammatory response induced by Pseudomonas aeruginosa in macrophages enhances apoptotic cell removal; Nature Research; Scientific Reports; 11; 1; 1-2021; 1-13
dc.identifier2045-2322
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8543399
dc.descriptionPathogens phagocytosis and the uptake of apoptotic cells (efferocytosis) are essential macrophages tasks, classically considered as mutually exclusive. Macrophages have been observed to polarize into either pro-inflammatory/microbicidal or anti-inflammatory/efferocytic phenotypes. However, macrophage functions have shown to be more complex. Furthermore, little is known about the regulation of efferocytosis under inflammatory conditions. In this study, we elucidate the modulation of the macrophage efferocytic function during an inflammatory stimulus. We find that bone marrow-derived macrophages (BMDM) are very efficient in engulfing both the bacterial pathogen Pseudomonas aeruginosa and apoptotic cells. BMDM showed a high bactericidal capacity unaffected by the concomitant presence of apoptotic material. Plasticity in macrophage programming, in response to changing environmental cues, may modulate efferocytic capability. In this work, we further show that, after phagocyting and processing Pseudomonas aeruginosa, macrophages highly increase their efferocytic capacity without affecting their phagocytic function. Moreover, we demonstrate that Pseudomonas aeruginosa enhances efferocytosis of these phagocytes through the IL-6 signaling pathway. Our results show that the inflammatory response generated by the bacterial processing enhances these macrophages’ capacity to control inflammation through an increased efferocytosis.
dc.descriptionFil: Jager, Adriana Valeria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.descriptionFil: Arias, Paula Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.descriptionFil: Tribulatti, María Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.descriptionFil: Brocco, Marcela Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.descriptionFil: Pepe, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
dc.descriptionFil: Kierbel, Arlinet, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas; Argentina
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dc.languageeng
dc.publisherNature Research
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-021-81557-1
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-021-81557-1
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.subjectINLAMMATION
dc.subjectEFFEROCYTOSIS
dc.subjectMARCOPHAGES
dc.subjectPSEUDOMONA AERUGINOSA
dc.subjecthttps://purl.org/becyt/ford/1.6
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleThe inflammatory response induced by Pseudomonas aeruginosa in macrophages enhances apoptotic cell removal
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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