Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids

dc.creatorOrtiz, Javier Esteban
dc.creatorBerkov, Strahil
dc.creatorPigni, Natalia Belen
dc.creatorTheoduloz, Cristina
dc.creatorRoitman, German
dc.creatorTapia, Alejandro
dc.creatorBastida, Jaume
dc.creatorFeresin, Gabriela Egly
dc.date2012-11
dc.date.accessioned2023-08-31T00:23:51Z
dc.date.available2023-08-31T00:23:51Z
dc.identifierhttp://hdl.handle.net/11336/198703
dc.identifierOrtiz, Javier Esteban; Berkov, Strahil; Pigni, Natalia Belen; Theoduloz, Cristina; Roitman, German; et al.; Wild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids; Molecular Diversity Preservation International; Molecules; 17; 11; 11-2012; 13473-13482
dc.identifier1420-3049
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8543386
dc.descriptionThe Amaryllidaceae family is well known for its pharmacologically active alkaloids. An important approach to treat Alzheimer´s disease involves the inhibition of the enzyme acetylcholinesterase (AChE). Galanthamine, an Amaryllidaceae alkaloid, is an effective, selective, reversible, and competitive AChE inhibitor. This work was aimed at studying the alkaloid composition of four wild Argentinian Amarillydaceae species for the first time, as well as analyzing their inhibitory activity on acetylcholinesterase. Alkaloid content was characterized by means of GC-MS analysis. Chloroform basic extracts from Habranthus jamesonii, Phycella herbertiana, Rhodophiala mendocina and Zephyranthes filifolia collected in the Argentinian Andean region all contained galanthamine, and showed a strong AChE inhibitory activity (IC 50 between 1.2 and 2 μg/mL). To our knowledge, no previous reports on alkaloid profiles and AChEIs activity of wild Argentinian Amarillydaceae species have been publisihed. The demand for renewable sources of industrial products like galanthamine and the need to protect plant biodiversity creates an opportunity for Argentinian farmers to produce such crops.
dc.descriptionFil: Ortiz, Javier Esteban. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
dc.descriptionFil: Berkov, Strahil. Universidad de Barcelona; España
dc.descriptionFil: Pigni, Natalia Belen. Universidad de Barcelona; España. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.descriptionFil: Theoduloz, Cristina. Universidad de Talca; Chile
dc.descriptionFil: Roitman, German. Universidad de Buenos Aires. Facultad de Agronomía; Argentina
dc.descriptionFil: Tapia, Alejandro. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina
dc.descriptionFil: Bastida, Jaume. Universidad de Barcelona; España
dc.descriptionFil: Feresin, Gabriela Egly. Universidad Nacional de San Juan. Facultad de Ingeniería. Instituto de Biotecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan; Argentina
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dc.languageeng
dc.publisherMolecular Diversity Preservation International
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.3390/molecules171113473
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/1420-3049/17/11/13473
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectACETYLCHOLINESTERASE INHIBITORS
dc.subjectALKALOIDS
dc.subjectARGENTINIAN AMARYLLIDACEAE WILD
dc.subjectGALANTHAMINE
dc.subjectLYCORINE
dc.subjectTAZETTINE
dc.subjecthttps://purl.org/becyt/ford/1.4
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleWild argentinian amaryllidaceae, a new renewable source of the acetylcholinesterase inhibitor galanthamine and other alkaloids
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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