Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida)

dc.creatorLinck, Viviane M.
dc.creatorGanzella, Marcelo
dc.creatorHerrmann, Ana P.
dc.creatorOkunji, Christopher O.
dc.creatorSouza, Diogo O.
dc.creatorAntonelli, Marta Cristina
dc.creatorElisabetsky, Elaine
dc.date2015-01
dc.date.accessioned2023-08-31T00:10:50Z
dc.date.available2023-08-31T00:10:50Z
dc.identifierhttp://hdl.handle.net/11336/182647
dc.identifierLinck, Viviane M.; Ganzella, Marcelo; Herrmann, Ana P.; Okunji, Christopher O.; Souza, Diogo O.; et al.; Original mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida); Elsevier Gmbh; Phytomedicine; 22; 1; 1-2015; 52-55
dc.identifier0944-7113
dc.identifier1618-095X
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8543186
dc.descriptionAlstonine is the major component of plant based remedies that traditional psychiatrists use in Nigeria. Alstonine is an indole alkaloid that has an antipsychotic experimental profile comparable with that of clozapine and is compatible with the alleged effects in mental patients. Representing a desirable innovation in the pharmacodynamics of antipsychotic medications, the evidence indicates that alstonine does not bind to D2 dopamine receptors (D2R) and differentially regulates dopamine in the cortical and limbic areas. The purpose of this study was to further investigate the effects of alstonine on D2R binding in specific brain regions using quantitative autoradiography (QAR) and its effects on dopamine (DA) uptake in mouse striatal synaptosomes. The effects of alstonine on D2R binding were determined in the nucleus accumbens and caudate-putamen using QAR in mice treated with alstonine doses that have antipsychotic effects. The effects of alstonine [3H]DA uptake were assessed in synaptosomes prepared from striatal tissue obtained from mice treated acutely or for 7 days with alstonine. Alstonine did not change the D2R binding densities in the studied regions. DA uptake was increased after acute (but not after 7 days) treatment with alstonine. Consistent with the alstonine behavioral profile, these results indicate that alstonine indirectly modulates DA receptors, specifically by modulating DA uptake. This unique mechanism for DA transmission modulation contributes to the antipsychotic-like effects of alstonine and is compatible with its behavioral profile in mice and alleged effects in patients. These results may represent an innovation in the antipsychotic development field.
dc.descriptionFil: Linck, Viviane M.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Ganzella, Marcelo. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Herrmann, Ana P.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Okunji, Christopher O.. International Centre for Ethnomedicine and Drug Development; Nigeria
dc.descriptionFil: Souza, Diogo O.. Universidade Federal do Rio Grande do Sul; Brasil
dc.descriptionFil: Antonelli, Marta Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Biología Celular y Neurociencia "Prof. Eduardo de Robertis". Universidad de Buenos Aires. Facultad de Medicina. Instituto de Biología Celular y Neurociencia; Argentina
dc.descriptionFil: Elisabetsky, Elaine. Universidade Federal do Rio Grande do Sul; Brasil
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherElsevier Gmbh
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.phymed.2014.10.010
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0944711314003651
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subjectALSTONINE
dc.subjectANTIPSYCHOTICS
dc.subjectD2 DOPAMINE RECEPTOR
dc.subjectDOPAMINE UPTAKE
dc.subjectINDOLE ALKALOID
dc.subjectPICRALIMA NITIDA
dc.subjectSCHIZOPHRENIA
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleOriginal mechanisms of antipsychotic action by the indole alkaloid alstonine (Picralima nitida)
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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