An ovine model of postinfarction dilated cardiomyopathy in animals with highly variable coronary anatomy

dc.creatorLocatelli, Paola
dc.creatorOlea, Fernanda Daniela
dc.creatorMendiz, Oscar
dc.creatorSalmo, Fabián
dc.creatorFazzi, Lucía
dc.creatorHnatiuk, Anna
dc.creatorLaguens, Rubén
dc.creatorCrottogini, Alberto Jose
dc.date2011-04
dc.date.accessioned2023-08-30T23:51:39Z
dc.date.available2023-08-30T23:51:39Z
dc.identifierhttp://hdl.handle.net/11336/192502
dc.identifierLocatelli, Paola; Olea, Fernanda Daniela; Mendiz, Oscar; Salmo, Fabián; Fazzi, Lucía; et al.; An ovine model of postinfarction dilated cardiomyopathy in animals with highly variable coronary anatomy; Oxford University Press; Ilar Journal; 52; 1; 4-2011; 16-21
dc.identifier1930-6180
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8542856
dc.descriptionStudies on cardiac regeneration require large mammalian models of dilated cardiomyopathy (DCM) after acute myocardial infarction (AMI), and pig and sheep models are increasingly used in this field of preclinical research. Given the large interindividual variability in ovine left anterior descending artery (LAD) anatomy, protocols based on the coronary arteries to be ligated often lead to significant variation in infarct sizes and hence to heterogeneous results, ranging from no ventricular remodeling to acute, lethal left ventricular (LV) failure. We designed an ovine model of postinfarction DCM based on estimated infarct size rather than on a predetermined menu of coronary artery ligatures. In seven adult sheep we induced an anterolateral AMI of approximately 25% of the LV mass by ligating the branches of the LAD that, by visual inspection, would lead to such an infarct size. In 10 to 12 weeks, LV end-diastolic volume more than doubled and LV end-systolic volume almost tripled. LV ejection fraction decreased dramatically, as did LV percent fractional shortening and LV percent wall thickening. Infarct size (planimetry) was approximately 25% of the LV endocardial surface. We conclude that in sheep, an anterolateral AMI of approximately 25% of the LV mass--regardless of the coronary branches ligated to attain that infarct size--results in a model of postinfarction DCM that may prove useful in preclinical research on myocardial regeneration.
dc.descriptionFil: Locatelli, Paola. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
dc.descriptionFil: Olea, Fernanda Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
dc.descriptionFil: Mendiz, Oscar. Fundación Favaloro; Argentina
dc.descriptionFil: Salmo, Fabián. Fundación Favaloro; Argentina
dc.descriptionFil: Fazzi, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Fundación Favaloro; Argentina
dc.descriptionFil: Hnatiuk, Anna. Universidad Favaloro; Argentina
dc.descriptionFil: Laguens, Rubén. Fundación Favaloro; Argentina
dc.descriptionFil: Crottogini, Alberto Jose. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
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dc.languageeng
dc.publisherOxford University Press
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/ilarjournal/article/52/1/E16/648991
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1093/ilar.52.1.E16
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectACUTE MYOCARDIAL INFARCTION
dc.subjectDILATED CARDIOMYOPATHY
dc.subjectLEFT ANTERIOR DESCENDING ARTERY
dc.subjectLIGATURE
dc.subjectOVINE MODEL
dc.subjectSHEEP
dc.subjecthttps://purl.org/becyt/ford/3.1
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleAn ovine model of postinfarction dilated cardiomyopathy in animals with highly variable coronary anatomy
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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