Inositols: from established knowledge to novel approaches

dc.creatorDinicola, Simona
dc.creatorUnfer, Vittorio
dc.creatorFacchinetti, Fabio
dc.creatorSoulage, Christophe O.
dc.creatorGreene, Nicholas D.
dc.creatorBizzarri, Mariano
dc.creatorLaganà, Antonio Simone
dc.creatorChan, Shiao Yng
dc.creatorBevilacqua, Arturo
dc.creatorPkhaladze, Lali
dc.creatorBenvenga, Salvatore
dc.creatorStringaro, Annarita
dc.creatorBarbaro, Daniele
dc.creatorAppetecchia, Marialuisa
dc.creatorAragona, Cesare
dc.creatorEspinola, Maria Salomè Bezerra
dc.creatorCantelmi, Tonino
dc.creatorCavalli, Pietro
dc.creatorChiu, Tony T.
dc.creatorCopp, Andrew J.
dc.creatorD'Anna, Rosario
dc.creatorDewailly, Didier
dc.creatordi Lorenzo, Cherubino
dc.creatorDiamanti Kandarakis, Evanthia
dc.creatorMarín, Imelda Hernández
dc.creatorHod, Moshe
dc.creatorKamenov, Zdravko
dc.creatorKandaraki, Eleni
dc.creatorMonastra, Giovanni
dc.creatorOliva, Mario Montanino
dc.creatorNestler, John E.
dc.creatorNordio, Maurizio
dc.creatorOzay, Ali C.
dc.creatorPapalou, Olga
dc.creatorPorcaro, Giuseppina
dc.creatorPrapas, Nikos
dc.creatorRoseff, Scott
dc.creatorVazquez, Monica Hebe
dc.creatorVucenik, Ivana
dc.creatorWdowiak, Artur
dc.date2021-10
dc.date.accessioned2023-08-30T23:47:32Z
dc.date.available2023-08-30T23:47:32Z
dc.identifierhttp://hdl.handle.net/11336/203888
dc.identifierDinicola, Simona; Unfer, Vittorio; Facchinetti, Fabio; Soulage, Christophe O.; Greene, Nicholas D.; et al.; Inositols: from established knowledge to novel approaches; MDPI; International Journal of Molecular Sciences; 22; 19; 10-2021; 1-30
dc.identifier1661-6596
dc.identifier1422-0067
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8542784
dc.descriptionMyo-inositol (myo-Ins) and D-chiro-inositol (D-chiro-Ins) are natural compounds involved in many biological pathways. Since the discovery of their involvement in endocrine signal transduction, myo-Ins and D-chiro-Ins supplementation has contributed to clinical approaches in ameliorating many gynecological and endocrinological diseases. Currently both myo-Ins and D-chiro-Ins are well-tolerated, effective alternative candidates to the classical insulin sensitizers, and are useful treatments in preventing and treating metabolic and reproductive disorders such as polycystic ovary syndrome (PCOS), gestational diabetes mellitus (GDM), and male fertility disturbances, like sperm abnormalities. Moreover, besides metabolic activity, myo-Ins and D-chiro-Ins deeply influence steroidogenesis, regulating the pools of androgens and estrogens, likely in opposite ways. Given the complexity of inositol-related mechanisms of action, many of their beneficial effects are still under scrutiny. Therefore, continuing research aims to discover new emerging roles and mechanisms that can allow clinicians to tailor inositol therapy and to use it in other medical areas, hitherto unexplored. The present paper outlines the established evidence on inositols and updates on recent research, namely concerning D-chiro-Ins involvement into steroidogenesis. In particular, D-chiro-Ins mediates insulin-induced testosterone biosynthesis from ovarian thecal cells and directly affects synthesis of estrogens by modulating the expression of the aromatase enzyme. Ovaries, as well as other organs and tissues, are characterized by a specific ratio of myo-Ins to D-chiro-Ins, which ensures their healthy state and proper functionality. Altered inositol ratios may account for pathological conditions, causing an imbalance in sex hormones. Such situations usually occur in association with medical conditions, such as PCOS, or as a consequence of some pharmacological treatments. Based on the physiological role of inositols and the pathological implications of altered myo-Ins to D-chiro-Ins ratios, inositol therapy may be designed with two different aims: (1) restoring the inositol physiological ratio; (2) altering the ratio in a controlled way to achieve specific effects.
dc.descriptionFil: Dinicola, Simona. Sapienza Università di Roma. System Biology Group Lab; Italia
dc.descriptionFil: Unfer, Vittorio. Università di Modena e Reggio Emilia; Italia
dc.descriptionFil: Facchinetti, Fabio. Università di Modena e Reggio Emilia; Italia
dc.descriptionFil: Soulage, Christophe O.. Inserm; Francia
dc.descriptionFil: Greene, Nicholas D.. University College London; Estados Unidos
dc.descriptionFil: Bizzarri, Mariano. Sapienza Università di Roma. System Biology Group Lab; Italia. Università degli Studi di Roma "La Sapienza"; Italia
dc.descriptionFil: Laganà, Antonio Simone. Università degli Studi dell’Insubria. Ospedale Filippo del Ponte; Italia
dc.descriptionFil: Chan, Shiao Yng. National University of Singapore; Singapur
dc.descriptionFil: Bevilacqua, Arturo. Università degli Studi di Roma "La Sapienza"; Italia
dc.descriptionFil: Pkhaladze, Lali. Zhordania and Khomasuridze Institute of Reproductology; Georgia
dc.descriptionFil: Benvenga, Salvatore. Università degli Studi di Messina; Italia
dc.descriptionFil: Stringaro, Annarita. Istituto Superiore di Sanita; Italia
dc.descriptionFil: Barbaro, Daniele. Ospedale Civile Di Livorno; Italia
dc.descriptionFil: Appetecchia, Marialuisa. Regina Elena National Cancer Institute; Italia
dc.descriptionFil: Aragona, Cesare. Sapienza Università di Roma. System Biology Group Lab; Italia
dc.descriptionFil: Espinola, Maria Salomè Bezerra. Sapienza Università di Roma. System Biology Group Lab; Italia
dc.descriptionFil: Cantelmi, Tonino. Institute For Interpersonal Cognitive Therapy; Italia
dc.descriptionFil: Cavalli, Pietro. Humanitas Research Hospital; Italia
dc.descriptionFil: Chiu, Tony T.. IVF Centre; China
dc.descriptionFil: Copp, Andrew J.. University College London; Estados Unidos
dc.descriptionFil: D'Anna, Rosario. Università degli Studi di Messina; Italia
dc.descriptionFil: Dewailly, Didier. Université de Lille; Francia
dc.descriptionFil: di Lorenzo, Cherubino. Università degli studi di Roma "La Sapienza"; Italia
dc.descriptionFil: Diamanti Kandarakis, Evanthia. Hygeia Hospital; Grecia
dc.descriptionFil: Marín, Imelda Hernández. Universidad Nacional Autónoma de México; México
dc.descriptionFil: Hod, Moshe. Universitat Tel Aviv; Israel
dc.descriptionFil: Kamenov, Zdravko. Sofia University St. Kliment Ohridski; Bulgaria
dc.descriptionFil: Kandaraki, Eleni. Hygeia Hospital; Grecia
dc.descriptionFil: Monastra, Giovanni. Systems Biology Group Lab; Italia
dc.descriptionFil: Oliva, Mario Montanino. Sofia University St. Kliment Ohridski; Bulgaria
dc.descriptionFil: Nestler, John E.. Virginia Commonwealth University; Estados Unidos
dc.descriptionFil: Nordio, Maurizio. Azienda Sanitaria Locale Roma ; Italia
dc.descriptionFil: Ozay, Ali C.. Near East University Hospital; Chipre
dc.descriptionFil: Papalou, Olga. Hygeia Hospital; Grecia
dc.descriptionFil: Porcaro, Giuseppina. Azienda USL UMBRIA ; Italia
dc.descriptionFil: Prapas, Nikos. Iakentro; Grecia
dc.descriptionFil: Roseff, Scott. South Florida Institute for Reproductive Medicine; Estados Unidos
dc.descriptionFil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.descriptionFil: Vucenik, Ivana. University of Maryland; Estados Unidos
dc.descriptionFil: Wdowiak, Artur. Medical University Of Lublin (medical University Of Lublin);
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.3390/ijms221910575
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectAROMATASE
dc.subjectD-CHIRO-INOSITOL
dc.subjectEPIMERASE
dc.subjectFSH
dc.subjectGDM
dc.subjectMYO-INOSITOL
dc.subjectNEURAL TUBE DEFECTS
dc.subjectPCOS
dc.subjectSTEROIDOGENESIS
dc.subjectTESTOSTERONE
dc.subjecthttps://purl.org/becyt/ford/1.6
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleInositols: from established knowledge to novel approaches
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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