Paying the circadian toll: The circadian response to LPS injection is dependent on the Toll-like receptor 4

dc.creatorPaladino, Natalia
dc.creatorLeone, Maria Juliana
dc.creatorPlano, Santiago Andrés
dc.creatorGolombek, Diego Andres
dc.date2010-08
dc.date.accessioned2023-08-30T23:47:21Z
dc.date.available2023-08-30T23:47:21Z
dc.identifierhttp://hdl.handle.net/11336/190074
dc.identifierPaladino, Natalia; Leone, Maria Juliana; Plano, Santiago Andrés; Golombek, Diego Andres; Paying the circadian toll: The circadian response to LPS injection is dependent on the Toll-like receptor 4; Elsevier Science; Journal of Neuroimmunology; 225; 1-2; 8-2010; 62-67
dc.identifier0165-5728
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8542778
dc.descriptionSystemic low doses of the endotoxin lipopolysaccharide (LPS) administered at CT15 (circadian time 12 corresponds to locomotor activity onset) induce phase delays of locomotor activity rhythms in mice. To evaluate if this effect was mediated by the Toll-like receptor 4 (TLR4), our present aim was to characterize the circadian behavior and LPS-induced circadian response of TLR4 (LPS receptor)-deficient mice (in C57bl/10 and C3H backgrounds). In mutants, we observed a free-running period and a light-induced phase delay similar to the one observed in their corresponding wild-type (WT) littermates. The LPS-induced phase delay, wheel running inhibition and c-Fos/Per-1 immunoreactivity in the paraventricular nuclei observed in WT mice was absent or significantly decreased in the TLR4-deficient mice. In conclusion, we show that LPS-induced circadian responses are mediated by TLR4.
dc.descriptionFil: Paladino, Natalia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.descriptionFil: Leone, Maria Juliana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.descriptionFil: Plano, Santiago Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
dc.descriptionFil: Golombek, Diego Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología. Laboratorio de Cronobiología; Argentina
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dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S016557281000175X
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jneuroim.2010.04.015
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subjectCIRCADIAN
dc.subjectLPS
dc.subjectSUPRACHIASMATIC
dc.subjectTOLL 4 RECEPTOR
dc.subjecthttps://purl.org/becyt/ford/1.6
dc.subjecthttps://purl.org/becyt/ford/1
dc.titlePaying the circadian toll: The circadian response to LPS injection is dependent on the Toll-like receptor 4
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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