The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition

dc.creatorBruna, Flavia Alejandra
dc.creatorFernández, Katia
dc.creatorUrrejola, Felipe
dc.creatorTouma, Jorge
dc.creatorNavarro, Myriam
dc.creatorSepúlveda, Betsabet
dc.creatorLarrazabal Fuentes, María
dc.creatorParedes, Adrián
dc.creatorNeira, Iván
dc.creatorFerrando, Matías
dc.creatorOsorio, José Manuel
dc.creatorYañez, Osvaldo
dc.creatorBravo, Jessica
dc.date2022-11
dc.date.accessioned2023-08-30T23:44:15Z
dc.date.available2023-08-30T23:44:15Z
dc.identifierhttp://hdl.handle.net/11336/203452
dc.identifierBruna, Flavia Alejandra; Fernández, Katia; Urrejola, Felipe; Touma, Jorge; Navarro, Myriam; et al.; The essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition; Frontiers Media; Frontiers in Natural Products; 1; 11-2022; 1-16
dc.identifier2813-2602
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8542731
dc.descriptionThe Mapuche and their ancestors have used D. winteri in traditional medicine. In the present study, the essential oil extract of D. winteri leaves (DW_EO) were characterized chemically and biologically to evaluate its pharmacological activity. In vitro antioxidant activity was assayed, and antitumor activity was evaluated in non-tumor and tumor-cell culture lines. Caenorhabditis elegans was used as a model to evaluate toxicity, and the chemical composition of the essential oil was analyzed by gas chromatography-mass spectrometry. The chemical oil composition was characterized principally of five major terpenes: 4 sesquiterpenes γ-Eudesmol (39.7%), β-Caryophyllene (33.7%), Elemol (25.9%), α-Eudesmol (0.3%) and 1 diterpene Kaunene (0.4%). By quantum calculations, it was determined that all oils have the ability to capture and yield electrons, which is consistent with the moderate antioxidant activity of DW_EO detected in vitro. Furthermore, by molecular docking is estimated that these oils can bind to proteins involved in the production of oxygen radicals. Of these proteins, CYP2C9 could bind energetically, reaching binding energy between −6.8 and −9.2 kCal/mol for the 5 terpenes studied, highlighting among these β-Caryophyllen and γ-Eudesmol. DW_EO has effect against H. pylori (MIC 32 μg/ml), S. aureus (MIC 8 μg/ml), E. coli (MIC 32 μg/ml) and C. albicans (MIC 64 μg/ml), β-Caryophyllen and γ -Eudesmol (MIC 64 μg/ml) and could selectively inhibit the proliferation of epithelial tumor cell lines but showed low against C. elegans (0.39–1.56 μg mL−1). Therefore, DW_EO may be used as a source of bioactive compounds in novel pharmacological treatments for medical application, agronomics, sanitation, and food.
dc.descriptionFil: Bruna, Flavia Alejandra. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina. Universidad Diego Portales; Chile
dc.descriptionFil: Fernández, Katia. Universidad Diego Portales; Chile
dc.descriptionFil: Urrejola, Felipe. Universidad Diego Portales; Chile
dc.descriptionFil: Touma, Jorge. Universidad Diego Portales; Chile
dc.descriptionFil: Navarro, Myriam. Universidad Diego Portales; Chile
dc.descriptionFil: Sepúlveda, Betsabet. Universidad de Chile; Chile
dc.descriptionFil: Larrazabal Fuentes, María. Universidad de Antofagasta (uantof);
dc.descriptionFil: Paredes, Adrián. Universidad de Antofagasta (uantof);
dc.descriptionFil: Neira, Iván. Universidad de Antofagasta (uantof);
dc.descriptionFil: Ferrando, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
dc.descriptionFil: Osorio, José Manuel. Universidad Diego Portales; Chile. Universidad Andrés Bello; Chile
dc.descriptionFil: Yañez, Osvaldo. Universidad de Las Américas.; Ecuador. Center of New Drugs for Hypertension; Chile
dc.descriptionFil: Bravo, Jessica. Universidad Diego Portales; Chile
dc.formatapplication/pdf
dc.formatapplication/pdf
dc.languageeng
dc.publisherFrontiers Media
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fntpr.2022.958425/full
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fntpr.2022.958425
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by/2.5/ar/
dc.subjectESSENTIAL OIL,
dc.subjectANTIOXIDANT ACTIVITY
dc.subjectCITOTOXICITY ACTIVITY
dc.subjectANTIMICROBIAL ACTIVITY
dc.subjectANTITUMORAL ACTIVITY
dc.subjecthttps://purl.org/becyt/ford/1.6
dc.subjecthttps://purl.org/becyt/ford/1
dc.titleThe essential oil from Drimys winteri possess activity: Antioxidant, theoretical chemistry reactivity, antimicrobial, antiproliferative and chemical composition
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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