Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds

dc.creatorGorzalczany, Susana Beatriz
dc.creatorLópez, Paula Gladys
dc.creatorAcevedo, C.
dc.creatorFerraro, Graciela Ester
dc.date2011-02
dc.date.accessioned2023-08-30T23:35:28Z
dc.date.available2023-08-30T23:35:28Z
dc.identifierhttp://hdl.handle.net/11336/198437
dc.identifierGorzalczany, Susana Beatriz; López, Paula Gladys; Acevedo, C.; Ferraro, Graciela Ester; Anti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds; Elsevier Ireland; Journal of Ethnopharmacology; 133; 3; 2-2011; 994-998
dc.identifier0378-8741
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8542608
dc.descriptionAim of the study: In this study the anti-inflammatory activity of aqueous, dichloromethane (CH2Cl2) and methanolic (MeOH) extracts and two major compounds isolated from Lithrea molleoides (Vell.) Engl. (Anacardiaceae) were evaluated. Materials and methods: Two classical experimental models were used, carrageenan-induced rat paw edema and 12-O-tetradecanoylphorbol-13 acetate (TPA) induced mouse ear edema. Results: MeOH extracts exhibited a significant systemical anti-inflammatory effect in the carrageenan (inhibition of 46% at 3 h) and in the TPA-ear edema test (inhibition of 21%). The presence of methyl gallate (inhibition of 63% in TPA ear edema), as one of the main compounds in the active fraction from MeOH extract may be explained the effect observed. Also, 1,3-dihydroxy-(Z,Z)-5-(tridec-4,7ˇıdienyl) benzene obtained from CH2Cl2 extract showed a significant topical anti-inflammatory activity (inhibition of 68%). Furthermore, no signs of toxicity were observed with doses up to 3 g/kg in an acute toxicity assay. Conclusions: The results of this study present evidence that Lithrea molleoides given either systemically or topically has anti-inflammatory properties.
dc.descriptionFil: Gorzalczany, Susana Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.descriptionFil: López, Paula Gladys. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
dc.descriptionFil: Acevedo, C.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Farmacología. Cátedra de Farmacología; Argentina
dc.descriptionFil: Ferraro, Graciela Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
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dc.languageeng
dc.publisherElsevier Ireland
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0378874110008160?via%3Dihub
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jep.2010.11.031
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject1,3-DIHYDROXY-(Z,Z)-5-(TRIDEC-4′,7DIENYL) BENZENE
dc.subjectANACARDIACEAE
dc.subjectANTI-INFLAMMATORY
dc.subjectCARRAGEENAN
dc.subjectLITHREA MOLLEOIDES
dc.subjectMETHYL GALLATE
dc.subjectTPA
dc.subjecthttps://purl.org/becyt/ford/3.3
dc.subjecthttps://purl.org/becyt/ford/3
dc.titleAnti-inflammatory effect of Lithrea molleoides extracts and isolated active compounds
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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