| dc.creator | Zucchetti, Andrés E. | |
| dc.creator | Goldenring, James R. | |
| dc.creator | Larocca, María Cecilia | |
| dc.date | 2023-03-27T15:55:06Z | |
| dc.date | 2023-03-27T15:55:06Z | |
| dc.date | 2023-01-12 | |
| dc.date | 2023-03-27T15:55:06Z | |
| dc.date | 2023-03-27T15:55:06Z | |
| dc.date | 2023-01-12 | |
| dc.date.accessioned | 2023-08-30T21:18:28Z | |
| dc.date.available | 2023-08-30T21:18:28Z | |
| dc.identifier | 2296-634X | |
| dc.identifier | http://hdl.handle.net/2133/25396 | |
| dc.identifier | http://hdl.handle.net/2133/25396 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8542235 | |
| dc.description | Cell polarity refers to the asymmetric distribution of cellular components along defined axes
of the cell, which constitutes a fundamental property of most cells, from single-cell organisms to
cells in multicellular invertebrates and vertebrates (Nelson, 2003). The ability of cells to generate
a specific spatially biased biochemical and morphological organization in response to distinct
extracellular or intracellular cues is critical for development and for specialized cell functions,
including directional cell migration, phagocytosis, epithelial secretion and absorption, immune
response, and transmission and transduction of information by the nervous system (Bryant and
Mostov, 2008). Furthermore, cell polarity has a main role in the control of epithelial cell growth,
what is underscored by the relationship between tumor suppressors and apico-basal polarity
and the fact that loss of polarity is an early hallmark of malignancy arising from epithelial
tissues, which constitute the major cause of fatal cancer in adults (Wodarz A and Näthke, 2007).
The attainment of the precise, time and spatially organized cell asymmetry in response to
extracellular and/or intracellular cues is triggered by different signals in each particular system,
but it is orchestrated by a common mechanistic pattern that comprise activation of
compartmentalized signaling pathways, major rearrangements of the cytoskeleton,
regulation of lipid landscape and polarized membrane trafficking (Figure 1). The present
Research Topic contains two review articles, two original research full articles and one brief
research report addressing cellular mechanisms that determine cell polarity, which have impact
on epithelial homeostasis, directional cell migration, phagocytosis and neuronal function. | |
| dc.description | Fil: Zucchetti, Andrés E. Research University. Institut Curie; France. | |
| dc.description | Fil: Goldenring, James R. Vanderbilt University School of Medicine. Epithelial Biology Center and Department of Cell & Developmental Biology; United States. | |
| dc.description | Fil: Larocca, María Cecilia. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Fisiología Experimental. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Frontiers Media S.A. | |
| dc.relation | https://doi.org/10.3389/fcell.2023.1119485 | |
| dc.relation | https://www.frontiersin.org/articles/10.3389/fcell.2023.1119485/full | |
| dc.rights | https://creativecommons.org/licenses/by/4.0 | |
| dc.rights | Zucchetti, Andrés E. | |
| dc.rights | Goldenring, James R. | |
| dc.rights | Larocca, María Cecilia | |
| dc.rights | Attribution 4.0 International (CC BY 4.0) | |
| dc.rights | openAccess | |
| dc.subject | Primary cilia | |
| dc.subject | Sonic hedgehog | |
| dc.subject | Cofilin | |
| dc.subject | Neuronal polarity | |
| dc.subject | Epithelial polarity | |
| dc.subject | Phosphoinositides | |
| dc.title | Editorial: Cell polarity: Trafficking and regulatory events that determine cell asymmetry | |
| dc.type | article | |
| dc.type | artículo | |
| dc.type | publishedVersion | |
