| dc.creator | Dizanzo, María Paula | |
| dc.creator | Bugnon Valdano, Marina Paula | |
| dc.creator | Basukala, Om | |
| dc.creator | Banks, Lawrence | |
| dc.creator | Gardiol, Daniela | |
| dc.date | 2022-12-13T15:05:11Z | |
| dc.date | 2022-12-13T15:05:11Z | |
| dc.date | 2022-12 | |
| dc.date | 2022-12-13T15:05:11Z | |
| dc.date | 2022-12-13T15:05:11Z | |
| dc.date | 2022-12 | |
| dc.date.accessioned | 2023-08-30T21:17:29Z | |
| dc.date.available | 2023-08-30T21:17:29Z | |
| dc.identifier | 1471-2407 | |
| dc.identifier | http://hdl.handle.net/2133/25026 | |
| dc.identifier | http://hdl.handle.net/2133/25026 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8541922 | |
| dc.description | Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both
E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety of
relevant cellular targets. Among them, the expression of some PDZ-containing polarity proteins, as DLG1 and hScrib,
is altered during the HPV life cycle and the consequent malignant transformation. Together with the well-established
interference of E6 with PDZ proteins, we have recently shown that E7 viral oncoprotein is also responsible for the
changes in abundance and localization of DLG1 observed in HPV-associated lesions. Given that the mechanisms
involved remained only partially understood, we here thoroughly analyse the contribution of a crucial E7 post-translational modifcation: its CKII-dependent phosphorylation. Moreover, we extended our studies to hScrib, in order to
investigate possible conserved regulatory events among diverse PDZ targets of HPV. | |
| dc.description | Fil: Dizanzo, María Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina. | |
| dc.description | Fil: Bugnon Valdano, Marina Paula. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina. | |
| dc.description | Fil: Gardiol, Daniela. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Biología Molecular y Celular de Rosario (IBR-CONICET); Argentina. | |
| dc.description | Fil: Basukala,Om. International Centre for Genetic Engineering and Biotechnology. Tumour Virology Laboratory; Italy. | |
| dc.description | Fil: Banks, Lawrence. International Centre for Genetic Engineering and Biotechnology. Tumour Virology Laboratory; Italy. | |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | BMC | |
| dc.relation | https://doi.org/10.1186/s12885-022-10105-5 | |
| dc.relation | https://bmccancer.biomedcentral.com/articles/10.1186/s12885-022-10105-5 | |
| dc.rights | https://creativecommons.org/licenses/by/4.0/ | |
| dc.rights | Dizanzo, María Paula | |
| dc.rights | Bugnon Valdano, Marina Paula | |
| dc.rights | Basukala,Om | |
| dc.rights | Banks, Lawrence | |
| dc.rights | Gardiol, Daniela | |
| dc.rights | Attribution 4.0 International (CC BY 4.0) | |
| dc.rights | openAccess | |
| dc.subject | HPV E7 | |
| dc.subject | CKII | |
| dc.subject | PDZ | |
| dc.subject | DLG1 hScrib | |
| dc.title | Novel effect of the high risk-HPV E7 CKII phospho-acceptor site on polarity protein expression | |
| dc.type | artículo | |
| dc.type | article | |
