Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic

dc.creatorStreinmaus, Craig
dc.creatorMoore, Lee E.
dc.creatorShipp, Miriam
dc.creatorKalman, Dave
dc.creatorRey, Omar A.
dc.creatorBiggs, Mary Lou
dc.creatorHopenhayn, Claudia
dc.creatorBates, Michael N.
dc.creatorZheng, Schichun
dc.creatorWiencke, John
dc.creatorSmith, Allan H.
dc.date2007-01-01
dc.date.accessioned2023-08-30T17:09:24Z
dc.date.available2023-08-30T17:09:24Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/4043/1/A_Streinmaus.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8539772
dc.descriptionMethylation is the primary route of metabolism of inorganic arsenic in humans, and previous studies showed that interindividual differences in arsenic methylation may have important impacts on susceptibility to arsenic-induced cancer. To date, the factors that regulate arsenic methylation in humans are mostly unknown. Urinary arsenic methylation patterns and genetic polymorphisms in methylenetetrahydrofolate reductase (MTHFR) and glutathione S-transferase (GST) were investigated in 170 subjects from an arsenic-exposed region in Argentina. Previous studies showed that subjects with the TT/AA polymorphisms at MTHFR 677 and 1298 have lower MTHFR activity than others. In this study, it was found that subjects with the TT/AA variant of MTHFR 677/1298 excreted a significantly higher proportion of ingested arsenic as inorganic arsenic and a lower proportion as dimethylarsinic acid. Women with the null genotype of GSTM1 excreted a significantly higher proportion of arsenic as monomethylarsonate than women with the active genotype. No associations were seen between polymorphisms in GSTT1 and arsenic methylation. This is the first study to report (1) associations between MTHFR and arsenic metabolism in humans, and (2) gender differences between genetic polymorphisms and urinary arsenic methylation patterns. Overall, this study provides evidence that MTHFR and GSTM1 are involved in arsenic metabolism in humans, and polymorphisms in the genes that encode these enzymes may play a role in susceptibility to arsenic-induced cancer.
dc.descriptionFil: Streinmaus, Craig. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Moore, Lee E. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Shipp, Miriam. Occupational and Environmental Medicine, University of California, San Francisco, CA, United States
dc.descriptionFil: Kalman, Dave. School of Public Health and Community Medicine, University of Washington, Seattle, WA, United States
dc.descriptionFil: Rey, Omar A. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Biggs, Mary Lou. Fred Hutchinson Cancer Research Center, Seattle, WA, United States
dc.descriptionFil: Hopenhayn, Claudia. College of Public Health, University of Kentucky, Lexington, KY, United States
dc.descriptionFil: Bates, Michael N. School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Zheng, Schichun. Department of Neurological Surgery, University of California, San Francisco, CA, United States
dc.descriptionFil: Wiencke, John. Department of Neurological Surgery, University of California, San Francisco, CA, United States
dc.descriptionFil: Smith, Allan H. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.formatapplication/pdf
dc.languagespa
dc.relationhttp://pa.bibdigital.ucc.edu.ar/4043/
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1080/15287390600755240
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceStreinmaus, Craig, Moore, Lee E., Shipp, Miriam, Kalman, Dave, Rey, Omar A. ORCID: https://orcid.org/0000-0002-9232-1252 <https://orcid.org/0000-0002-9232-1252>, Biggs, Mary Lou, Hopenhayn, Claudia, Bates, Michael N., Zheng, Schichun, Wiencke, John ORCID: https://orcid.org/0000-0001-7101-6489 <https://orcid.org/0000-0001-7101-6489> and Smith, Allan H. (2007) Genetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic. Journal of Toxicology and Environmental Health - Part A: Current Issues, 70 (2). pp. 159-170. ISSN 1087-2620
dc.subjectR Medicina (General)
dc.titleGenetic polymorphisms in MTHFR 677 and 1298, GSTM1 and T1, and metabolism of arsenic
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/acceptedVersion


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