| dc.creator | Palacios, Sara María | |
| dc.creator | Palacio, Marcela A. | |
| dc.date | 2007-06-11 | |
| dc.date.accessioned | 2023-08-30T17:09:22Z | |
| dc.date.available | 2023-08-30T17:09:22Z | |
| dc.identifier | http://pa.bibdigital.ucc.edu.ar/4026/1/A_Palacios_Palacio.pdf | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8539755 | |
| dc.description | Albuterol is a β2-adrenoceptor agonist prescribed for the treatment of bronchial asthma; it exists as a racemate and its bronchodilator activity resides in the (R)-isomer or levalbuterol. The aim of this study was to determine a methodology that would separate the enantiomers of albuterol by preferential crystallization after a conglomerate is identified within its derivatives. We found that albuterol sulfate behaves as a conglomerate showing the characteristic αx-value = 2 (mole fraction solubility ratio of racemate vs enantiomer), the V-shaped ternary phase diagram and the preferential crystallization by seeding with the pure enantiomer. On the basis of these characteristics, we separated the enantiomers by entrainment, and crystallizing out a saturated methanolic solution of albuterol sulfate at 15 °C. | |
| dc.description | Fil: Palacios, Sara María. Universidad Católica de Córdoba. Facultad de Ciencias Químicas; Argentina | |
| dc.description | Fil: Palacio, Marcela A. Agencia Córdoba Ciencia SE, Unidad CEPROCOR, 5164, Santa Maria dePunilla, Cordoba, Argentina | |
| dc.format | application/pdf | |
| dc.language | spa | |
| dc.relation | http://pa.bibdigital.ucc.edu.ar/4026/ | |
| dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tetasy.2007.05.010 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.rights | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.source | Palacios, Sara María and Palacio, Marcela A. (2007) Enantiomeric resolution of albuterol sulfate by preferential crystallization. Tetrahedron Asymmetry, 18 (10). pp. 1170-1175. ISSN 1362-511X | |
| dc.subject | QD Química | |
| dc.title | Enantiomeric resolution of albuterol sulfate by preferential crystallization | |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:ar-repo/semantics/artículo | |
| dc.type | info:eu-repo/semantics/acceptedVersion | |
