Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism

dc.creatorDouthat, Walter Guillermo
dc.creatorOrozco, Santiago E.
dc.creatorMaino, Pablo
dc.creatorCardozo, Gabriela
dc.creatorArteaga, Javier de
dc.creatorFuente, Jorge de la
dc.creatorChirchiu, Carlos R.
dc.creatorMassari, Pablo U.
dc.date2007-12-31
dc.date.accessioned2023-08-30T17:09:20Z
dc.date.available2023-08-30T17:09:20Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/4013/1/A_Douthat_Orozco_Maino_Cardozo_Arteaga_Fuente_Chirchiu_Massari.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8539742
dc.descriptionPersistent hyperparathyroidism is frequent in postrenal transplant patients. Percutaneous ethanol injection therapy (PEIT) is an alternative for treatment of patients with secondary hyperparathyroidism but it was not described in postrenal transplant patients. We report our experience with PEIT to control hyperparathyroidism in the post-transplant period. We performed PEIT under ultrasonographic guidance and local anesthesia in eight patients because of persistent secondary hyperparathyroidism after renal transplantation. Indications for PEIT were: high intact parathyroid hormone (iPTH) levels with hypercalcemia, hypophosphatemia, osteopenia and/or bone pain. All patients had at least one visible parathyroid nodule by ultrasonography. Biochemical assays were performed immediately before PEIT, between 1 and 7 days after last PEIT, and a mean of 8.0 ± 2.8 months after PEIT. Serum iPTH and calcium levels decreased significantly after treatment and remained unchanged until final control. Serum iPTH decreased from 286.9 ± 107.2 to 154.6 ± 42.2 pg/ml (P < 0.01) after PEIT (percentual reduction 36.5 ± 9.5%). This response was significantly correlated to total ethanol volume used (r: 0.94, P < 0.0001). Hypercalcemia disappeared in six of eight patients treated. Only minor complications were registered. There were no changes in renal function related to the treatment. Our findings show that PEIT is a useful and safe alternative for patients with persistent post-transplant secondary hyperparathyroidism.
dc.descriptionFil: Douthat, Walter Guillermo. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Orozco, Santiago E. Department of Radiology, Hospital Privado-Centro Médico de Córdoba, Córdoba, Argenti
dc.descriptionFil: Maino, Pablo. Department of Radiology, Hospital Privado-Centro Médico de Córdoba, Córdoba, Argentina
dc.descriptionFil: Cardozo, Gabriela. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Arteaga, Javier de. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Fuente, Jorge de la. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Chirchiu, Carlos R. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Massari, Pablo U. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.formatapplication/pdf
dc.languagespa
dc.relationhttp://pa.bibdigital.ucc.edu.ar/4013/
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1111/j.1432-2277.2007.00545.x
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceDouthat, Walter Guillermo ORCID: https://orcid.org/0000-0002-4644-6003 <https://orcid.org/0000-0002-4644-6003>, Orozco, Santiago E., Maino, Pablo, Cardozo, Gabriela, Arteaga, Javier de, Fuente, Jorge de la, Chirchiu, Carlos R. and Massari, Pablo U. (2007) Percutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism. Transplant International, 20 (12). pp. 1031-1035. ISSN 1432-2277
dc.subjectR Medicina (General)
dc.titlePercutaneous ethanol injection therapy in post-transplant patients with secondary hyperparathyroidism
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/acceptedVersion


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