Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States

dc.creatorSteinmaus, Craig
dc.creatorBates, Michael N.
dc.creatorYuan, Yan
dc.creatorKalman, Dave
dc.creatorAtallah, Raja
dc.creatorRey, Omar A.
dc.creatorBiggs, Mary Lou
dc.creatorHopenhayn, Claudia
dc.creatorMoore, Lee E.
dc.creatorHoang, Bruce K.
dc.creatorSmith, Allan H.
dc.date2006-12-31
dc.date.accessioned2023-08-30T17:09:19Z
dc.date.available2023-08-30T17:09:19Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/4002/1/A_Steinmaus_Bates_Yuan_Kalman_Atallah_Rey_Biggs_Hopenhayn_Moore_Hoang_Smith.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8539731
dc.descriptionObjective: We sought to assess whether the metabolism of arsenic impacts a person's susceptibility to bladder cancer. Methods: Urinary methylation products were measured in subjects from Argentina (114 cases and 114 controls) and the United States (23 cases and 49 controls). Results: In Argentina, the adjusted odds ratio (OR) for subjects with a high proportion of ingested arsenic excreted as monomethylarsonate (%MMA) was 2.17 (95% confidence interval [CI] = 1.02-4.63) in smokers and 0.48 (95% CI = 0.17-1.33) in nonsmokers. In the United States, the adjusted ORs for high %MMA in subjects with arsenic intakes less than and greater than 100 μg/d were 1.20 (95% CI = 0.27-5.38) and 2.70 (95% CI = 0.39-18.6). Conclusions: Overall, these results are consistent with data from Taiwan suggesting that some individuals who excrete a higher proportion of ingested arsenic as MMA are more susceptible to arsenic-related cancer.
dc.descriptionFil: Steinmaus, Craig. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Bates, Michael N. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Yuan, Yan. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Kalman, Dave. School of Public Health and Community Medicine, University of Washington, Seattle, WA, United States
dc.descriptionFil: Atallah, Raja. School of Public Health and Community Medicine, University of Washington, Seattle, WA, United States
dc.descriptionFil: Rey, Omar A. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Biggs, Mary Lou. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Hopenhayn, Claudia. College of Public Health, Markey Cancer Control Program, University of Kentucky, Lexington, KY, United States
dc.descriptionFil: Moore, Lee E. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.descriptionFil: Hoang, Bruce K. Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, United States
dc.descriptionFil: Smith, Allan H. Arsenic Health Effects Research Program, School of Public Health, University of California, Berkeley, CA, United States
dc.formatapplication/pdf
dc.languagespa
dc.relationhttp://pa.bibdigital.ucc.edu.ar/4002/
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1097/01.jom.0000200982.28276.70
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceSteinmaus, Craig ORCID: https://orcid.org/0000-0003-2697-843X <https://orcid.org/0000-0003-2697-843X>, Bates, Michael N., Yuan, Yan, Kalman, Dave, Atallah, Raja, Rey, Omar A. ORCID: https://orcid.org/0000-0002-9232-1252 <https://orcid.org/0000-0002-9232-1252>, Biggs, Mary Lou, Hopenhayn, Claudia, Moore, Lee E., Hoang, Bruce K. and Smith, Allan H. (2006) Arsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States. Journal of Occupational and Environmental Medicine, 48 (5). pp. 478-488. ISSN 1076-2752
dc.subjectR Medicina (General)
dc.titleArsenic methylation and bladder cancer risk in case-control studies in Argentina and the United States
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/acceptedVersion


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