Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina

dc.creatorMoore, Lee E.
dc.creatorWiencke, John
dc.creatorBates, Michael N.
dc.creatorZheng, Schichun
dc.creatorRey, Omar C.
dc.creatorSmith, Allan H.
dc.date2004-08-10
dc.date.accessioned2023-08-30T17:09:16Z
dc.date.available2023-08-30T17:09:16Z
dc.identifierhttp://pa.bibdigital.ucc.edu.ar/3978/1/A_Moore_Wiencke_Bates_Zheng_Rey_Smith.pdf
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8539707
dc.descriptionWe investigated the role of glutathione S-transferase (GST) enzymes (M1, T1), methylenetetrahydrofolate (MTHFR) 677 and 1298, and the NAD(P)H:quinone oxidoreductase (NQO1) polymorphisms in a population-based bladder cancer case-control study in Argentina. Buccal cell DNA was obtained from 106 cases and 109 controls. The strongest evidence was for an interaction between NQO1 genotype and smoking. For ever smoking vs. never smoking the odds ratio was 8.6 (95% confidence interval (CI) 2.7-27), in the CC genotype, and 1.3 (95% CI 0.5-3.5) in the CT and TT genotypes combined. Also, elevated bladder cancer risks associated with GSTM1 and GSTT1 null genotypes were found in smokers. Having both null polymorphisms conferred the highest risks. The MTHFR 677 CT and TT polymorphisms appeared protective against bladder cancer.
dc.descriptionFil: Moore, Lee E. School of Public Health, Arsenic Hlth. Effects Res. Program, University of California, Berkeley, CA 94720-7360, United States
dc.descriptionFil: Wiencke, John. Univ. California S. Francisco C., San Francisco, CA, United States
dc.descriptionFil: Bates, Michael N. School of Public Health, Arsenic Hlth. Effects Res. Program, University of California, Berkeley, CA 94720-7360, United States
dc.descriptionFil: Zheng, Schichun. Univ. California S. Francisco C., San Francisco, CA, United States
dc.descriptionFil: Rey, Omar C. Universidad Católica de Córdoba. Facultad de Ciencias de la Salud; Argentina
dc.descriptionFil: Smith, Allan H. School of Public Health, Arsenic Hlth. Effects Res. Program, University of California, Berkeley, CA 94720-7360, United States
dc.formatapplication/pdf
dc.languagespa
dc.relationhttp://pa.bibdigital.ucc.edu.ar/3978/
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.canlet.2004.04.011
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.sourceMoore, Lee E., Wiencke, John ORCID: https://orcid.org/0000-0001-7101-6489 <https://orcid.org/0000-0001-7101-6489>, Bates, Michael N., Zheng, Schichun, Rey, Omar C. ORCID: https://orcid.org/0000-0002-9232-1252 <https://orcid.org/0000-0002-9232-1252> and Smith, Allan H. (2004) Investigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina. Cancer Letters, 211 (2). pp. 199-207. ISSN 0304-3835
dc.subjectR Medicina (General)
dc.titleInvestigation of genetic polymorphisms and smoking in a bladder cancer case-control study in Argentina
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/acceptedVersion


Este ítem pertenece a la siguiente institución