Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases

dc.creatorVallés, Ana Sofía
dc.creatorBarrantes, Francisco José
dc.date2023-08-25T13:15:27Z
dc.date2023-08-25T13:15:27Z
dc.date2023
dc.date.accessioned2023-08-30T15:42:36Z
dc.date.available2023-08-30T15:42:36Z
dc.identifierVallés, A. S., Barrantes, F. J. Nicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases [en línea]. Cells. 2023, 12(16). doi:10.3390/cells12162051. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16987
dc.identifier2073-4409 (online)
dc.identifierhttps://repositorio.uca.edu.ar/handle/123456789/16987
dc.identifier10.3390/cells12162051
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8527123
dc.descriptionAbstract: The cholinergic system plays an essential role in brain development, physiology, and pathophysiology. Herein, we review how specific alterations in this system, through genetic mutations or abnormal receptor function, can lead to aberrant neural circuitry that triggers disease. The review focuses on the nicotinic acetylcholine receptor (nAChR) and its role in addiction and in neurodegenerative and neuropsychiatric diseases and epilepsy. Cholinergic dysfunction is associated with inflammatory processes mainly through the involvement of α7 nAChRs expressed in brain and in peripheral immune cells. Evidence suggests that these neuroinflammatory processes trigger and aggravate pathological states. We discuss the preclinical evidence demonstrating the therapeutic potential of nAChR ligands in Alzheimer disease, Parkinson disease, schizophrenia spectrum disorders, and in autosomal dominant sleep-related hypermotor epilepsy. PubMed and Google Scholar bibliographic databases were searched with the keywords indicated below.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rightsAcceso abierto
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceCells.Vol.12, No.16, 2023
dc.subjectENFERMEDAD DE ALZHEIMER
dc.subjectENFERMEDAD DE PARKINSON
dc.subjectEPILEPSIA
dc.subjectESPECTRO DE ESQUIZOFRENIA
dc.subjectADICCIONES
dc.subjectSALUD
dc.subjectENFERMEDADES
dc.titleNicotinic acetylcholine receptor dysfunction in addiction and in some neurodegenerative and neuropsychiatric diseases
dc.typeArtículo


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