Nanomicellar formulations loaded with histamine and paclitaxel as a new strategy to improve chemotherapy for breast cáncer

dc.contributor0000-0003-2513-5975
dc.creatorNicoud, Melisa Beatriz
dc.creatorOspital, Ignacio
dc.creatorTáquez Delgado, Mónica Alejandra
dc.creatorRiedel, Jennifer
dc.creatorFuentes, Pedro
dc.creatorBernabeu, Ezequiel
dc.creatorRubinstein Guichón, Mara Roxana
dc.creatorLauretta, Paolo
dc.creatorMartínez Vivot, Rocío
dc.creatorAguilar, María de los Angeles
dc.creatorSalgueiro, María J.
dc.creatorSpeisky, Daniela
dc.creatorMoretton, Marcela A.
dc.creatorChiappetta, Diego A.
dc.creatorMedina, Vanina A.
dc.date2023-05-29T10:44:51Z
dc.date2023-05-29T10:44:51Z
dc.date2023
dc.date.accessioned2023-08-30T15:40:10Z
dc.date.available2023-08-30T15:40:10Z
dc.identifierNicoud, M.B., et al. Nanomicellar formulations loaded with histamine and paclitaxel as a new strategy to improve chemotherapy for breast cáncer [en línea]. International Journal of Molecular Sciences. 2023, 24(4) doi: 10.3390/ijms24043546. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/16409
dc.identifier1422-0067
dc.identifierhttps://repositorio.uca.edu.ar/handle/123456789/16409
dc.identifier10.3390/ijms24043546
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8526558
dc.descriptionAbstract: Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype. Currently, paclitaxel (PTX) represents the first-line therapy for TNBC; however it presents a hydrophobic behavior and produces severe adverse effects. The aim of this work is to improve the therapeutic index of PTX through the design and characterization of novel nanomicellar polymeric formulations composed of a biocompatible copolymer Soluplus® (S), surface-decorated with glucose (GS), and co-loaded either with histamine (HA, 5 mg/mL) and/or PTX (4 mg/mL). Their micellar size, evaluated by dynamic light scattering, showed a hydrodynamic diameter between 70 and 90 nm for loaded nanoformulations with a unimodal size distribution. Cytotoxicity and apoptosis assays were performed to assess their efficacy in vitro in human MDA-MB-231 and murine 4T1 TNBC cells rendering optimal antitumor efficacy in both cell lines for the nanoformulations with both drugs. In a model of TNBC developed in BALB/c mice with 4T1 cells, we found that all loaded micellar systems reduced tumor volume and that both HA and HA-PTX-loaded SG micelles reduced tumor weight and neovascularization compared with the empty micelles. We conclude that HA-PTX co-loaded micelles in addition to HA-loaded formulations present promising potential as nano-drug delivery systems for cancer chemotherapy.
dc.formatapplication/pdf
dc.languageeng
dc.publisherMDPI
dc.rightsAcceso abierto
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourceInternational Journal of Molecular Sciences. 2023, 24(4)
dc.subjectCANCER DE MAMA TRIPLE NEGATIVO
dc.subjectHISTAMINA
dc.subjectFORMULACION NANOMICELAR
dc.subjectTERAPIA DE COMBINACION
dc.subjectMICELAS POLIMERICAS
dc.subjectAPOPTOSIS
dc.titleNanomicellar formulations loaded with histamine and paclitaxel as a new strategy to improve chemotherapy for breast cáncer
dc.typeArtículo


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