Melatonin : a promising drug to ameliorate main human space exploration risks

dc.creatorVigo, Daniel Eduardo
dc.creatorPlano, Santiago Andrés
dc.creatorDemaría Pesce, Víctor
dc.creatorCardinali, Daniel Pedro
dc.date2022-11-04T16:13:16Z
dc.date2022-11-04T16:13:16Z
dc.date2022
dc.date.accessioned2023-08-30T15:36:05Z
dc.date.available2023-08-30T15:36:05Z
dc.identifierVigo, D. E. et al. Melatonin : a promising drug to ameliorate main human space exploration risks [en línea]. En: Pathak, Y.V., Araújo dos Santos, M., Zea, L. (eds). Handbook of Space Pharmaceuticals. Cham : Springer, 2022. doi: 10.1007/978-3-030-05526-4_56. Disponible en: https://repositorio.uca.edu.ar/handle/123456789/15401
dc.identifier978-3-030-05525-7 (impreso)
dc.identifier978-3-030-05526-4 (online)
dc.identifierhttps://repositorio.uca.edu.ar/handle/123456789/15401
dc.identifier10.1007/978-3-030-05526-4_56
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8525600
dc.descriptionAbstract: Melatonin is a small indole molecule synthesized by most cells in the mammalian body. Circulating melatonin secreted by the pineal gland is a circadian signal that regulates main rhythmic physiological processes, including sleep-wake cycle and biological rhythms in cardiovascular function, metabolism, and immune response. Both intracellular and extracellular melatonin have been shown to act as an effective protector for free radicals molecular and tissue injury. During human space exploration crewmembers will be exposed to several risks, including exposure to radiation in the form of high-energy galactic cosmic rays and solar particle events, bone loss and neurological disorders induced by microgravity, and sleep disruption. Due to its important chronobiotic and cytoprotective effect, melatonin treatment could be a potential effective strategy to protect against most space radiation hazards. It has an anti-osteoclastogenic activity and a pro-osteoblastic activity that may reduce bone-loss induced by microgravity. Also, melatonin is potentially effective to prevent neurodegeneration that may result from long term space exploration. Finally, its chronobiotic and hypnotic properties may help to improve sleep and circadian synchronization, decreasing in turn, the risk of fatigue, performance decrements and adverse health outcomes. Melatonin was presumably present from the very beginning of life in Earth and evidence suggests that it could be a helpful partner for our first steps outside the planet.
dc.formatapplication/pdf
dc.languageeng
dc.publisherSpringer
dc.rightsAcceso restringido
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.sourcePathak, Y.V., Araújo dos Santos, M., Zea, L. (eds). Handbook of Space Pharmaceuticals. Cham : Springer, 2022
dc.subjectMELATONINA
dc.subjectFISIOLOGIA
dc.subjectGLANDULA PINEAL
dc.subjectRITMO CIRCADIANO
dc.subjectESPACIO
dc.subjectRADIACION
dc.titleMelatonin : a promising drug to ameliorate main human space exploration risks
dc.typeParte de libro


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