Clinical case definitions for Argentine hemorrhagic fever

dc.creatorHarrison, Lee H
dc.creatorHalsey, Neal A.
dc.creatorMcKee Jr, Kelly T.
dc.creatorPeters, Clarence J.
dc.creatorBarrera Oro, Julio G.
dc.creatorBriggiler, Ana M.
dc.creatorFeuillade, María Rosa
dc.creatorMaiztegui, Julio I.
dc.date2021-02-01T20:16:46Z
dc.date2021-02-01T20:16:46Z
dc.date1999-05
dc.date.accessioned2023-08-29T20:09:17Z
dc.date.available2023-08-29T20:09:17Z
dc.identifier1058-4838
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2285
dc.identifier10.1086/514749
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520605
dc.descriptionFil: Harrison, Lee H. University of Pittsburgh Graduate School of Public Health,Pittsburgh, Pennsylvania; Estados Unidos.
dc.descriptionFil: Halsey, Neal A. Department of International Health, Johns Hopkins Medical Institutions, Baltimore, Maryland; Estados Unidos.
dc.descriptionFil: McKee, Kelly T. Womack Army Medical Center, Fort Bragg, North Carolina; Estados Unidos.
dc.descriptionFil: Peters, Clarence J. Special Pathogens Branch, Centers for Disease Control, Atlanta, Georgia; Estados Unidos
dc.descriptionFil: Barrera Oro, Julio G. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
dc.descriptionFil: Briggiler, Ana M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
dc.descriptionFil: Feuillade, Maria Rosa. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
dc.descriptionFil: Maiztegui, Julio I. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas; Argentina.
dc.descriptionArgentine hemorrhagic fever (AHF) is a potentially lethal infection in Argentina. The case-fatality ratio is >15%, but treatment reduces the mortality rate to <1%. Diagnosis is based on clinical and laboratory criteria, but no case definition has been validated. A chart review was conducted for patients hospitalized with suspected AHF. Individuals with a fourfold rise in antibody titer were classified as cases. The combination of a platelet count of <100,000/mm3 and a white blood cell (WBC) count of <2,500/mm3 had a sensitivity and specificity of 87% and 88%, respectively, thus suggesting that the use of these criteria in a case definition would be helpful for epidemiological studies of AHF. The combination of a platelet count of <100,000/mm3 and a WBC count of <4,000/mm3 had a sensitivity of 100% and a specificity of 71%; the use of these criteria in a case definition should be helpful for screening patients for therapy with immune plasma in the region where AHF is endemic.
dc.languageen
dc.relationClinical infectious diseases : an official publication of the Infectious Diseases Society of America
dc.rightsnone
dc.subjectInfecciones por Arenaviridae
dc.subjectArenavirus del Nuevo Mundo
dc.subjectVirus Junin
dc.titleClinical case definitions for Argentine hemorrhagic fever
dc.typeArtículo


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