Trends of Two Epidemic Multidrug-Resistant Strains of Mycobacterium tuberculosis in Argentina Disclosed by Tailored Molecular Strategy

dc.creatorMonteserin, Johana
dc.creatorPérez-Lago, Laura
dc.creatorYokobori, Noemi
dc.creatorPaul, Roxana
dc.creatorRodríguez Maus, Sandra
dc.creatorSimboli, Norberto
dc.creatorEldholm, Vegard
dc.creatorLópez, Beatriz
dc.creatorGarcia de Viedma, Dario
dc.creatorRitacco, Viviana
dc.date2021-01-20T13:27:52Z
dc.date2021-01-20T13:27:52Z
dc.date2019
dc.date.accessioned2023-08-29T20:09:01Z
dc.date.available2023-08-29T20:09:01Z
dc.identifier0002-9637
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2197
dc.identifier10.4269/ajtmh.19-0397
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520467
dc.descriptionFil: Monteserin, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Pérez-Lago, Laura. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionFil: Yokobori, Noemí. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Paul, Roxana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Rodríguez Maus, Sandra. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionFil: Simboli, Norberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Eldholm, Vegard. Norwegian Institute of Public Health, Oslo; Noruega.
dc.descriptionFil: López, Beatriz. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: García de Viedma, Darío. Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionFil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionTwo Mycobacterium tuberculosis strains-M (sublineage 4.1) and Ra (sublineage 4.3)-have long prevailed in Argentina among patients with multidrug-resistant tuberculosis (MDR-TB). Recently, budget constraints have hampered the surveillance of MDR-TB transmission. Based on whole-genome sequence analysis, we used M- and Ra-specific single nucleotide polymorphisms to tailor two multiplex allele-specific polymerase chain reactions (PCRs), which we applied to 252 stored isolates (95% of all newly diagnosed MDR-TB cases countrywide, 2015-2017). Compared with the latest data available (2007-2009), the M strain has receded (80/324 to 20/252, P < 0.0001), particularly among cross-border migrants (12/58 to 0/53, P = 0.0003) and HIV-infected people (30/97 to 7/74, P = 0.0007), but it still accounts for 4/12 new cases of extensively drug-resistant TB. Differently, the Ra strain remained stable in frequency (39/324 to 33/252) and contributed marginally to the extensive drug-resistance load (1/12). Our novel strategy disclosed recent trends of the two major MDR-TB strains, providing meaningful data to allocate control interventions more efficiently.
dc.formatpdf
dc.languageen
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.relationThe American journal of tropical medicine and hygiene
dc.rightsopen
dc.sourceThe American Journal of Tropical Medicine and Hygiene 2019; 101(6):1308-1311.
dc.subjectMycobacterium tuberculosis
dc.subjectArgentina
dc.titleTrends of Two Epidemic Multidrug-Resistant Strains of Mycobacterium tuberculosis in Argentina Disclosed by Tailored Molecular Strategy
dc.typeArtículo


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