Burden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta-analysis

dc.creatorLinhares, Alexandre C
dc.creatorStupka, Juan A.
dc.creatorCiapponi, Agustin
dc.creatorBardach, Ariel
dc.creatorGlujovsky, Demian
dc.creatorAruj, Patricia
dc.creatorMazzoni, Agustina
dc.creatorRodriguez, Jefferson
dc.creatorRearte, Analía
dc.creatorLanzieri, Tatiana
dc.creatorOrtega-Barria, Eduardo
dc.creatorColindres, Romulo
dc.date2021-01-07T20:45:17Z
dc.date2021-01-07T20:45:17Z
dc.date2011-03
dc.date.accessioned2023-08-29T20:08:30Z
dc.date.available2023-08-29T20:08:30Z
dc.identifierhttp://iah.iec.pa.gov.br/iah/fulltext/pc/artigos/2011/revmedvirol2011prelo.pdf
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2078
dc.identifier10.1002/rmv.682
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520202
dc.descriptionFil: Linhares, Alexandre C. Instituto Evandro Chagas. Secretaria de Vigilancia em Saúde. Virology Section; Brasil.
dc.descriptionFil: Stupka, Juan A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Virología. Laboratorio de Gastroenteritis Virales; Argentina.
dc.descriptionFil: Ciapponi, Agustín. Instituto de Efectividad Clínica y Sanitaria; Argentina.
dc.descriptionFil: Bardach, Ariel. Instituto de Efectividad Clínica y Sanitaria; Argentina.
dc.descriptionFil: Glujovsky, Demián. Instituto de Efectividad Clínica y Sanitaria; Argentina.
dc.descriptionFil: Aruj, Patricia. Instituto de Efectividad Clínica y Sanitaria; Argentina.
dc.descriptionFil: Mazzoni, Agustina. Instituto de Efectividad Clínica y Sanitaria; Argentina.
dc.descriptionFil: Rodriguez, Jefferson. Instituto de Efectividad Clínica y Sanitaria; Argentina
dc.descriptionFil: Rearte, Analía. Instituto de Efectividad Clínica y Sanitaria; Argentina.
dc.descriptionFil: Lanzieri, Tatiana. GlaxoSmithKline Biologicals; Brasil.
dc.descriptionFil: Ortega-Barria, Eduardo. GlaxoSmithKline Biologicals; Brasil.
dc.descriptionFil: Colindres, Romulo. GlaxoSmithKline Biologicals; Brasil.
dc.descriptionThe efficacy of licensed rotavirus vaccines has only been shown against certain rotavirus group A (RV-A) types. It is critical to understand the burden of rotavirus gastroenteritis (RVGE) and its prevalent types to assess the potential impact of these vaccines in Latin America and the Caribbean (LA&C). We performed a systematic review and meta-analyses of all the available evidence reported from 1990 to 2009 on the burden of rotavirus disease and strains circulating in LA&C. Eligible studies--185 country-level reports, 174 951 faecal samples--were selected from MEDLINE, Cochrane Library, EMBASE, LILACS, regional Ministries of Health, PAHO, regional proceedings, doctoral theses, reference lists of included studies and consulting experts. Arc-sine transformations and DerSimonian-Laird random-effects model were used for meta-analyses. The proportion of gastroenteritis cases due to rotavirus was 24.3% (95%CI 22.3-26.4) and the incidence of RVGE was 170 per 1000 children-years (95%CI 130-210). We estimated a global annual mortality for 22 countries of 88.2 (95%CI 79.3-97.1) deaths per 100 000 under 5 years (47 000 deaths).The most common G type detected was G1 (34.2%), followed by G9 (14.6%), and G2 (14.4%). The most common P types detected were P[8] (56.2%), P[4] (22.1%) and P[1] 5.4%, and the most prevalent P-G type associations were P[8]G1 17.9%, P[4]G2 9.1% and P[8]G9 8.8%. In the last 10 years, G9 circulation increased remarkably and G5 almost disappeared. More recently, G12 appeared and P[4]G2 re-emerged. To our knowledge, this is the first meta-analysis of rotavirus infection and burden of disease in LA&C.
dc.languageen
dc.relationReviews in medical virology
dc.rightsnone
dc.subjectRotavirus
dc.subjectVacunas contra Rotavirus
dc.subjectGastroenteritis
dc.subjectAmerica Latina
dc.titleBurden and typing of rotavirus group A in Latin America and the Caribbean: systematic review and meta-analysis
dc.typeArtículo


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