Tyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis

dc.creatorGonzález Guerrico, Anatilde M.
dc.creatorCafferata, Eduardo
dc.creatorRadrizzani, Martin
dc.creatorMarcucci, Florencia
dc.creatorGruenert, Dieter
dc.creatorPivetta, Omar H.
dc.creatorFavaloro, Roberto R
dc.creatorLaguens, Rubén
dc.creatorPerrone, Sergio V
dc.creatorGallo, Guillermo C
dc.creatorSanta-Coloma, Tomás A.
dc.date2021-01-07T20:43:24Z
dc.date2021-01-07T20:43:24Z
dc.date2002-05-10
dc.date.accessioned2023-08-29T20:08:28Z
dc.date.available2023-08-29T20:08:28Z
dc.identifier0021-9258
dc.identifierhttps://www.jbc.org/content/277/19/17239.long
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/2071
dc.identifier10.1074/jbc.M112456200
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520186
dc.descriptionFil: González Guerrico, Anatilde M. Instituto de Investigaciones Bioquı́micas Fundación Campomar (UBA, CONICET), 1405 Buenos Aires; Argentina.
dc.descriptionFil: Cafferata, Eduardo. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.
dc.descriptionFil: Radrizzani, Martín. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.
dc.descriptionFil: Marcucci, Florencia. Instituto de Investigaciones Bioquı́micas Fundación Campomar (UBA, CONICET), 1405 Buenos Aires; Argentina.
dc.descriptionFil: Gruenert, Dieter. Human Molecular Genetics Unit, Department of Medicine, University of Vermont, Burlington; Estados Unidos.
dc.descriptionFil: Pivetta, Omar H. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.
dc.descriptionFil: Favaloro, Roberto R. Fundación Favaloro, 1093 Buenos Aires; Argentina.
dc.descriptionFil: Laguens, Rubén. Fundación Favaloro, 1093 Buenos Aires; Argentina.
dc.descriptionFil: Perrone, Sergio V. Fundación Favaloro, 1093 Buenos Aires; Argentina.
dc.descriptionFil: Gallo, Guillermo C. Hospital de Pediatrı́a Prof. Dr. Juan P. Garrahan, 1425 Buenos Aires; Argentina.
dc.descriptionFil: Santa-Coloma, Tomás A. Instituto de Investigaciones Bioquı́micas Fundación Campomar (UBA, CONICET), 1405 Buenos Aires; Argentina.
dc.descriptionCystic fibrosis (CF), a disease caused by mutations in the cystic fibrosis transmembrane regulator (CFTR) chloride channel, is associated in the respiratory system with the accumulation of mucus and impaired lung function. The role of the CFTR channel in the regulation of the intracellular pathways that determine the overexpression of mucin genes is unknown. Using differential display, we have observed the differential expression of several mRNAs that may correspond to putative CFTR-dependent genes. One of these mRNAs was further characterized, and it corresponds to the tyrosine kinase c-Src. Additional results suggest that c-Src is a central element in the pathway connecting the CFTR channel with MUC1 overexpression and that the overexpression of mucins is a primary response to CFTR malfunction in cystic fibrosis, which occurs even in the absence of bacterial infection.
dc.formatpdf
dc.languageen
dc.publisherAmerican Society for Biochemistry and Molecular Biology
dc.relationThe Journal of biological chemistry
dc.rightsopen
dc.sourceJournal of Biological Chemistry 2002; 277(19):17239-47.
dc.subjectTiroxina
dc.subjectFibrosis Quística
dc.titleTyrosine kinase c-Src constitutes a bridge between cystic fibrosis transmembrane regulator channel failure and MUC1 overexpression in cystic fibrosis
dc.typeArtículo


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