Gene synteny and evolution of genome architecture in trypanosomatids

dc.creatorGhedin, Elodie
dc.creatorBringaud, Frédéric
dc.creatorPeterson, Jeremy
dc.creatorMyler, Peter J.
dc.creatorBerriman, Matthew
dc.creatorIvens, Alasdair
dc.creatorAndersson, Björn
dc.creatorBontempi, Esteban J.
dc.creatorEisen, Jonathan
dc.creatorAngiuoli, Sam
dc.creatorWanless, David
dc.creatorVon Arx, Anna
dc.creatorMurphy, Lee
dc.creatorLennard, Nicola
dc.creatorSalzberg, Steven L.
dc.creatorAdams, Mark D
dc.creatorWhite, Owen
dc.creatorHall, Neil
dc.creatorStuart, Kenneth D.
dc.creatorFraser, Claire M.
dc.creatorEl-Sayed, Najib M A
dc.date2020-12-21T18:42:49Z
dc.date2020-12-21T18:42:49Z
dc.date2004-04
dc.date.accessioned2023-08-29T20:08:07Z
dc.date.available2023-08-29T20:08:07Z
dc.identifier0166-6851
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1959
dc.identifier10.1016/j.molbiopara.2003.11.012
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8520011
dc.descriptionFil: Ghedin, Elodie. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: Bringaud, Frederic. Université Victor Segalen de Bordeaux II. Laboratoire de Parasitologie Moléculaire; Francia.
dc.descriptionFil: Peterson, Jeremy. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: Myler, Peter. Seattle Biomedical Research Institute; Estados Unidos.
dc.descriptionFil: Berriman, Matthew. The Wellcome Trust Genome Campus. The Wellcome Trust Sanger Institute; Inglaterra.
dc.descriptionFil: Ivens, Alasdair. The Wellcome Trust Genome Campus. The Wellcome Trust Sanger Institute; Inglaterra.
dc.descriptionFil: Andersson, Björn. Karolinska Institute. Center for Genomics and Bioinformatics; Suecia.
dc.descriptionFil: Bontempi, Esteban. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Eisen, Jonathan. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: Angiuoli, Sam. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: Wanless, David. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: Von Arx, Anna. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: Murphy, Lee. The Wellcome Trust Genome Campus. The Wellcome Trust Sanger Institute; Inglaterra.
dc.descriptionFil: Lennard, Nicola. The Wellcome Trust Genome Campus. The Wellcome Trust Sanger Institute; Inglaterra.
dc.descriptionFil: Salzberg, Steven. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: Adams, Mark D. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: White, Owen. The Wellcome Trust Genome Campus. The Wellcome Trust Sanger Institute; Inglaterra.
dc.descriptionFil: Hall, Neil. The Wellcome Trust Genome Campus. The Wellcome Trust Sanger Institute; Inglaterra.
dc.descriptionFil: Stuart, Kenneth. Seattle Biomedical Research Institute; Estados Unidos.
dc.descriptionFil: Fraser, Claire M. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionFil: El-Sayed, Najib M A. The Institute for Genomic Research. Parasite Genomics; Estados Unidos.
dc.descriptionThe trypanosomatid protozoa Trypanosoma brucei, Trypanosoma cruzi and Leishmania major are related human pathogens that cause markedly distinct diseases. Using information from genome sequencing projects currently underway, we have compared the sequences of large chromosomal fragments from each species. Despite high levels of divergence at the sequence level, these three species exhibit a striking conservation of gene order, suggesting that selection has maintained gene order among the trypanosomatids over hundreds of millions of years of evolution. The few sites of genome rearrangement between these species are marked by the presence of retrotransposon-like elements, suggesting that retrotransposons may have played an important role in shaping trypanosomatid genome organization. A degenerate retroelement was identified in L. major by examining the regions near breakage points of the synteny. This is the first such element found in L. major suggesting that retroelements were found in the common ancestor of all three species.
dc.languageen
dc.publisherElsevier
dc.relation#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.relationdatasets
dc.relationMolecular and biochemical parasitology
dc.rightsnone
dc.sourceMolecular and Biochemical Parasitology 2004; 134(2):183-91
dc.subjectAnimales
dc.subjectBiología Computacional
dc.subjectOrden Génico
dc.subjectGenómica
dc.subjectLeishmania major
dc.subjectFamilia de Multigenes
dc.subjectRecombinación Genética
dc.subjectRetroelementos
dc.subjectSelección Genética
dc.subjectTrypanosoma brucei brucei
dc.subjectTrypanosoma cruzi
dc.subjectTrypanosomatina
dc.subjectEvolución Molecular
dc.subjectGenoma de Protozoos
dc.subjectSintenía
dc.titleGene synteny and evolution of genome architecture in trypanosomatids
dc.typeArtículo


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