Profile of cytokines in the lungs of BALB/c mice after intra-nasal infection with Histoplasma capsulatum mycelial propagules

dc.creatorSahaza, Jorge H
dc.creatorSuárez-Alvarez, Roberto
dc.creatorEstrada-Bárcenas, Daniel Alfonso
dc.creatorPérez-Torres, Armando
dc.creatorTaylor, Maria Lucia
dc.date2020-12-21T20:56:17Z
dc.date2020-12-21T20:56:17Z
dc.date2015-08
dc.date.accessioned2023-08-29T20:08:06Z
dc.date.available2023-08-29T20:08:06Z
dc.identifier0147-9571
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1969
dc.identifier10.1016/j.cimid.2015.05.003
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519996
dc.descriptionFil: Sahaza, Jorge H. Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM); México.
dc.descriptionFil: Suárez-Alvarez, Roberto. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
dc.descriptionFil: Estrada-Bárcenas, Daniel Alfonso. Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM); México.
dc.descriptionFil: Pérez-Torres, Armando. Laboratorio de Filogenia del Sistema Inmune de Piel y Mucosas, Departamento de Biología Celular y Tisular, Facultad de Medicina, UNAM; México.
dc.descriptionFil: Taylor, Maria Lucia. Laboratorio de Inmunología de Hongos, Unidad de Micología, Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México (UNAM); México.
dc.descriptionThe host pulmonary response to the fungus Histoplasma capsulatum was evaluated, through the profile of cytokines detected by the MagPix magnetic beads platform in lung homogenates and by lung-granulomas formation, from mice intra-nasally infected with mycelial propagules (M-phase) of two virulent H. capsulatum strains, EH-46 and G-217B. Results highlight that mice lung inflammatory response depends on the H. capsulatum strain used, during the first step of the fungal infection. IL-1β and TNF-α increased their concentrations in mice infected with both strains. The highest levels of IL-6, IL-17, and IL-23 were found in EH-46-infected mice, whereas levels of IL-22 were variable at all post-infection times for both strains. Significant increases of IL-12, IFN-γ, IL-4, and IL-10 were associated to EH-46-infected mice. Histological lung findings from EH-46-infected mice revealed incipient and numerous well-developed granulomas, distributed in lung-lobes at the 14th and the 21st days after infection, according to cytokine profiles.
dc.languageen
dc.publisherElsevier
dc.relationComparative immunology, microbiology and infectious diseases
dc.rightsnone
dc.sourceComparative Immunology, Microbiology and Infectious Diseases 2015; 41:1-9.
dc.subjectPulmón
dc.subjectCitocinas
dc.subjectHistoplasma
dc.titleProfile of cytokines in the lungs of BALB/c mice after intra-nasal infection with Histoplasma capsulatum mycelial propagules
dc.typeArtículo


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