Prevalence of antibody to hantaviruses in humans and rodents in the Caribbean region of Colombia determined using Araraquara and Maciel virus antigens

dc.creatorGuzman, Camilo
dc.creatorMattar, Salim
dc.creatorLevis, Silvana
dc.creatorPini, Noemí
dc.creatorFigueiredo, Tadeu
dc.creatorMills, James N.
dc.creatorSalazar-Bravo, Jorge
dc.date2020-12-18T16:01:11Z
dc.date2020-12-18T16:01:11Z
dc.date2013-04
dc.date.accessioned2023-08-29T20:08:01Z
dc.date.available2023-08-29T20:08:01Z
dc.identifier0074-0276
dc.identifier1678-8060
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1945
dc.identifier10.1590/0074-0276108022013007
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519951
dc.descriptionFil: Guzmán, Camilo. Instituto de Investigaciones Biológicas del Trópico, Córdoba, Montería; Colombia.
dc.descriptionFil: Mattar, Salim. Instituto de Investigaciones Biológicas del Trópico, Córdoba, Montería; Colombia.
dc.descriptionFil: Levis, Silvana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas “Dr. Julio MAIZTEGUI”; Argentina.
dc.descriptionFil: Pini, Noemí. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Virales Humanas “Dr. Julio MAIZTEGUI”; Argentina.
dc.descriptionFil: Figueiredo, Tadeu. Universidade de São Paulo. Faculdade de Medicina de Ribeirão Preto. Centro de Pesquisa em Virologia; Brasil.
dc.descriptionFil: Mills, James N. Medical Ecology. Centers for Disease Control and Prevention; Estados Unidos.
dc.descriptionFil: Salazar-Bravo, Jorge. Texas Tech University. Department of Biological Sciences; Estados Unidos.
dc.descriptionWe tested sera from 286 agricultural workers and 322 rodents in the department of Córdoba, northeastern Colombia, for antibodies against two hantaviruses. The sera were analysed by indirect ELISA using the lysate of Vero E6 cells infected with Maciel virus (MACV) or the N protein of Araraquara virus (ARAV) as antigens for the detection of antibodies against hantaviruses. Twenty-four human sera were IgG positive using one or both antigens. We detected anti-MACV IgG antibodies in 10 sera (3.5%) and anti-ARAV antibodies in 21 sera (7.34%). Of the 10 samples that were positive for MACV, seven (70%) were cross-reactive with ARAV; seven of the 21 ARAV-positive samples were cross-reactive with MACV. Using an ARAV IgM ELISA, two of the 24 human sera (8.4%) were positive. We captured 322 rodents, including 210 Cricetidae (181 Zygodontomys brevicauda, 28 Oligoryzomys fulvescens and 1 Oecomys trinitatis), six Heteromys anomalus (Heteromyidae), one Proechimys sp. (Echimyidae) and 105 Muridae (34 Rattus rattus and 71 Mus musculus). All rodent sera were negative for both antigens. The 8.4% detection rate of hantavirus antibodies in humans is much higher than previously found in serosurveys in North America, suggesting that rural agricultural workers in northeastern Colombia are frequently exposed to hantaviruses. Our results also indicate that tests conducted with South American hantavirus antigens could have predictive value and could represent a useful alternative for the diagnosis of hantavirus infection in Colombia.
dc.formatpdf
dc.languageen
dc.relationMemorias do Instituto Oswaldo Cruz
dc.rightsopen
dc.sourceMemórias do Instituto Oswaldo Cruz 2013;108(2):161-171
dc.subjectHantavirus
dc.subjectMonitoreo Epidemiológico
dc.subjectRoedores
dc.subjectSalud Pública
dc.subjectInmunoensayo
dc.titlePrevalence of antibody to hantaviruses in humans and rodents in the Caribbean region of Colombia determined using Araraquara and Maciel virus antigens
dc.typeArtículo


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