Evidence for unapparent Brucella canis infections among adults with occupational exposure to dogs

dc.creatorKrueger, W S
dc.creatorLucero, Nidia E.
dc.creatorBrower, A
dc.creatorHeil, G L
dc.creatorGray, G C
dc.date2020-12-17T00:08:24Z
dc.date2020-12-17T00:08:24Z
dc.date2014-11
dc.date.accessioned2023-08-29T20:07:55Z
dc.date.available2023-08-29T20:07:55Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1924
dc.identifier10.1111/zph.12102
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519911
dc.descriptionFil: Krueger, W S. University of Florida. College of Public Health & Health Professions. Emerging Pathogens Institute; Estados Unidos.
dc.descriptionFil: Lucero, Nidia E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Laboratorio de Brucelosis; Argentina.
dc.descriptionFil: Brower, A. University of Nottingham. School of Veterinary Medicine and Science; Reino Unido.
dc.descriptionFil: Heil, G L. University of Florida. College of Public Health & Health Professions. Emerging Pathogens Institute; Estados Unidos.
dc.descriptionFil: Gray, G C. University of Florida. College of Public Health & Health Professions. Emerging Pathogens Institute; Estados Unidos.
dc.descriptionHuman serological assays designed to detect brucellosis will miss infections caused by Brucella canis, and low levels of periodic bacteremia limit diagnosis by blood culture. Recent B. canis outbreaks in dogs and concomitant illnesses in caretakers suggest that unapparent human infections may be occurring. With more than a quarter of a million persons in occupations involving dogs, and nearly 80 million dog owners in the United States, this pathogen is an under-recognized human health threat. To investigate occupational exposure to B. canis, we adapted a commercial canine serological assay and present the first controlled seroepidemiological study of human B. canis infections in recent years. 306 adults with occupational exposure to dogs and 101 non-matched, non-canine-exposed subjects were enrolled. Antibodies were detected using the canine D-Tec(®) CB rapid slide agglutination test (RSAT) kit with a secondary 2-mercaptoethanol (ME)-RSAT. Results were validated on a blinded subset of sera with an additional RSAT and indirect enzyme-linked immunoassay at the National Administration of Laboratories and Health Institutes (ANLIS) in Argentina. Seroprevalence ranged from 10.8% (RSAT) to 3.6% (ME-RSAT) among canine-exposed subjects. Kennel employees were more likely to test RSAT seropositive compared with other canine exposures (OR = 2.7; 95% CI, 1.3-5.8); however, low seroprevalence limited meaningful occupational risk factor analyses. Two seropositive participants reported experiencing symptoms consistent with brucellosis and having exposure to B. canis-infected dogs; however, temporality of symptom onset with reported exposure could not be determined. D-Tec(®) CB results had substantial agreement with ANLIS assays (Cohen's kappa = 0.60-0.68). These data add to a growing body of literature suggesting that people occupationally exposed to dogs may be at risk of unapparent B. canis infection. It seems prudent to consider B. canis as an occupational public health concern and encourage the development of serological assays to detect human B. canis infections.
dc.languageen
dc.publisherWiley
dc.relation#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.relationdatasets
dc.relationZoonoses and public health
dc.rightsnone
dc.sourceZoonoses and Public Health 2014; 61(7):509-518
dc.subjectBrucelosis
dc.subjectEnfermedades Transmisibles
dc.subjectExposición Profesional
dc.subjectEstudios Seroepidemiológicos
dc.subjectZoonosis
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectAnciano
dc.subjectAnimales
dc.subjectAnticuerpos Antibacterianos
dc.subjectBrucella canis
dc.subjectEstudios de Casos y Controles
dc.subjectEstudios Transversales
dc.subjectEnfermedades de los Perros
dc.subjectPerros
dc.subjectEnsayo de Inmunoadsorción Enzimática
dc.subjectFemenino
dc.subjectFlorida
dc.subjectHumanos
dc.subjectIowa
dc.subjectMasculino
dc.subjectPersona de Mediana Edad
dc.subjectExposición Profesional
dc.subjectReproducibilidad de los Resultados
dc.subjectFactores de Riesgo
dc.subjectEstudios Seroepidemiológicos
dc.subjectEncuestas y Cuestionarios
dc.subjectAdulto Joven
dc.titleEvidence for unapparent Brucella canis infections among adults with occupational exposure to dogs
dc.typeArtículo


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