Antimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates

dc.creatorFaccone, Diego
dc.creatorVeliz, Omar
dc.creatorCorso, Alejandra
dc.creatorNoguera, Martín Ezequiel
dc.creatorMartínez, Melina
dc.creatorPayes, Cristian
dc.creatorSemorile, Liliana
dc.creatorMaffía, Paulo Cesar
dc.date2020-12-16T10:11:05Z
dc.date2020-12-16T10:11:05Z
dc.date2014-01
dc.date.accessioned2023-08-29T20:07:54Z
dc.date.available2023-08-29T20:07:54Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1920
dc.identifier10.1016/j.ejmech.2013.10.065
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519901
dc.descriptionFil: Faccone, Diego. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Veliz, Omar. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Noguera, Martin. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET); Argentina.
dc.descriptionFil: Martínez, Melina. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.
dc.descriptionFil: Payes, Cristian. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.
dc.descriptionFil: Semorile, Liliana. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.
dc.descriptionFil: Maffía, Paulo Cesar. Universidad Nacional de Quilmes. Laboratorio de Microbiología Molecular; Argentina.
dc.descriptionAntibiotic resistance is one of the main problems concerning public health or clinical practice. Antimicrobial peptides appear as good candidates for the development of new therapeutic drugs. In this study we de novo designed a group of cationic antimicrobial peptides, analyzed its physicochemical properties, including its structure by circular dichroism and studied its antimicrobial properties against a panel of clinical isolates expressing different mechanisms of resistance. Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).
dc.languageen
dc.relationEuropean journal of medicinal chemistry
dc.rightsnone
dc.subjectDicroismo Circular
dc.subjectPéptidos Catiónicos Antimicrobianos
dc.subjectAntibacterianos
dc.subjectResistencia a Medicamentos
dc.titleAntimicrobial activity of de novo designed cationic peptides against multi-resistant clinical isolates
dc.typeArtículo


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