| dc.creator | Antúnez, María Inés | |
| dc.creator | Cardoni, Rita L. | |
| dc.date | 2020-12-06T00:42:11Z | |
| dc.date | 2020-12-06T00:42:11Z | |
| dc.date | 2004 | |
| dc.date.accessioned | 2023-08-29T20:07:39Z | |
| dc.date.available | 2023-08-29T20:07:39Z | |
| dc.identifier | 0014-4894 | |
| dc.identifier | http://sgc.anlis.gob.ar/handle/123456789/1840 | |
| dc.identifier | 10.1016/j.exppara.2004.03.008 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8519770 | |
| dc.description | Fil: Antúnez, María Inés. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | |
| dc.description | Fil: Cardoni, Rita L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | |
| dc.description | T and NK cells play a key role in resistance to Trypanosoma cruzi infections, mainly through IFN-gamma production. The expression of T and NK cells surface markers was studied in NWNA spleen cells of resistant C3H and susceptible BALB/c mice that release IFN-gamma in the early and late acute infection, respectively. In the progressively enlarged spleens, we found: (a) an increased percentage and number of NK blast cells as early as at 2 days post-infection (pi), (b) an enrichment of T and NK cells, in both the total and blast populations, during the late acute phase. At 17 days pi, there was also an accumulation of TCR- alphabeta+DX5+, NKT cells, mainly in resistant mice. At 21 days pi, the enrichment of NK cells ceased, while spleen cells and the T cell compartment continued their expansion. In the chronic stage, TCR-alphabeta+ blasts were expanded in both mouse strains, but NK blasts increased only in BALB/c that, unlike C3H mice, release IFN-gamma. As T and NK cell proliferation is not always associated to IFN-gamma release the experimental downregulation of their expansion to avoid tissue damage could be explored. | |
| dc.language | en | |
| dc.relation | Experimental parasitology | |
| dc.rights | none | |
| dc.source | Experimental Parasitology 2004;106(3-4):85-94. | |
| dc.subject | Trypanosoma cruzi | |
| dc.title | Trypanosoma cruzi: the expansion of NK, T, and NKT cells in the experimental infection | |
| dc.type | Artículo | |
