| dc.creator | Gorla, María Cecilia | |
| dc.creator | Cassiolato, Ana Paula | |
| dc.creator | Pinhata, Juliana Maira Watanabe | |
| dc.creator | de Moraes, Camile | |
| dc.creator | Corso, Alejandra | |
| dc.creator | Gagetti, Paula | |
| dc.creator | Lemos, Ana Paula | |
| dc.date | 2020-12-04T09:07:37Z | |
| dc.date | 2020-12-04T09:07:37Z | |
| dc.date | 2018-03 | |
| dc.date.accessioned | 2023-08-29T20:07:31Z | |
| dc.date.available | 2023-08-29T20:07:31Z | |
| dc.identifier | http://sgc.anlis.gob.ar/handle/123456789/1814 | |
| dc.identifier | 10.1099/jmm.0.000685 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8519699 | |
| dc.description | Fil: Gorla, Maria Cecília. Adolfo Lutz Institute. Bacteriology Department; Brasil. | |
| dc.description | Fil: Cassiolato, Ana Paula. Adolfo Lutz Institute. Bacteriology Department; Brasil. | |
| dc.description | Fil: Pinhata, Juliana Maira Watanabe. Adolfo Lutz Institute. Bacteriology Department; Brasil. | |
| dc.description | Fil: de Moraes, Camile. Ministry of Health. Secretariat of Health Surveillance; Brasil. | |
| dc.description | Fil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | |
| dc.description | Fil: Gagetti, Paula. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | |
| dc.description | Fil: Lemos, Ana Paula. Adolfo Lutz Institute. Bacteriology Department; Brasil. | |
| dc.description | To prevent secondary invasive meningococcal disease (IMD) cases and outbreaks, antimicrobial prophylaxis of high-risk contacts is indicated. This study reports two ciprofloxacin-resistant Neisseria meningitidis strains in Brazil. The 3523 N. meningitidis isolates collected throughout Brazil from 2009 to 2016 were evaluated for antimicrobial resistance. Meningococcal isolates showing minimal inhibitory concentrations, MICs≥0.125µg ml-1 to ciprofloxacin, were analysed to determine the presence of mutations in the quinolone resistance-determining regions (QRDRs) of gyrA and parC genes. Two ciprofloxacin-resistant N. meningitidis isolates were found, both presenting a single mutation in the quinolone resistance-determining region of the gyrA gene. These results confirmed that ciprofloxacin is still a first-line drug for chemoprophylaxis. However, we highlight the importance of continued surveillance to monitor the trends of N. meningitidis susceptibility profiles to the antimicrobials recommended for chemoprophylaxis and IMD treatment. | |
| dc.format | pdf | |
| dc.language | en | |
| dc.publisher | Microbiology Society | |
| dc.relation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| dc.relation | datasets | |
| dc.relation | Journal of medical microbiology | |
| dc.rights | open | |
| dc.source | Journal of Medical Microbiology 2018; 67:286-288 | |
| dc.subject | Ciprofloxacino | |
| dc.subject | Antibacterianos | |
| dc.subject | Brasil | |
| dc.subject | Girasa de ADN | |
| dc.subject | Topoisomerasa de ADN IV | |
| dc.subject | Farmacorresistencia Bacteriana | |
| dc.subject | Fluoroquinolonas | |
| dc.subject | Humanos | |
| dc.subject | Infecciones Meningocócicas | |
| dc.subject | Pruebas de Sensibilidad Microbiana | |
| dc.subject | Tipificación de Secuencias Multilocus | |
| dc.subject | Mutación | |
| dc.subject | Neisseria gonorrhoeae | |
| dc.subject | Neisseria meningitidis | |
| dc.subject | Quinolonas | |
| dc.title | Emergence of resistance to ciprofloxacin in Neisseria meningitidis in Brazil | |
| dc.type | Artículo | |
