Small plasmids harboring qnrB19: a model for plasmid evolution mediated by site-specific recombination at oriT and Xer sites

dc.creatorTran, Tung
dc.creatorAndres, Patricia
dc.creatorPetroni, Alejandro
dc.creatorSoler Bistué, Alfonso J. C.
dc.creatorAlbornoz, Ezequiel
dc.creatorZorreguieta, Angeles
dc.creatorReyes-Lamothe, Rodrigo
dc.creatorSherratt, David J
dc.creatorCorso, Alejandra
dc.creatorTolmasky, Marcelo E.
dc.date2020-12-02T14:28:34Z
dc.date2020-12-02T14:28:34Z
dc.date2012-04
dc.date.accessioned2023-08-29T20:07:21Z
dc.date.available2023-08-29T20:07:21Z
dc.identifier1098-6596
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1795
dc.identifier10.1128/AAC.06036-11
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519619
dc.descriptionFil: Tran, Tung. Center for Applied Biotechnology Studies, College of Natural Sciences and Mathematics, California State University Fullerton; Estados Unidos.
dc.descriptionFil: Andres, Patricia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Petroni, Alejandro. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Soler-Bistué, Alfonso. Fundación Instituto Leloir, CONICET, FCEyN, Universidad de Buenos Aires; Argentina
dc.descriptionFil: Albornoz, Ezequiel. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Zorreguieta, Angeles. Fundación Instituto Leloir, CONICET, FCEyN, Universidad de Buenos Aires; Argentina Fil: Reyes-Lamothe, Rodrigo. Division of Molecular Genetics, Department of Biochemistry, University of Oxford; Reino Unido.
dc.descriptionFil: Sherratt, David J. Division of Molecular Genetics, Department of Biochemistry, University of Oxford; Reino Unido.
dc.descriptionFil: Corso, Alejandra. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Bacteriología. Servicio Antimicrobianos; Argentina.
dc.descriptionFil: Tolmasky, Marcelo E. Center for Applied Biotechnology Studies, College of Natural Sciences and Mathematics, California State University Fullerton; Estados Unidos.
dc.descriptionPlasmids pPAB19-1, pPAB19-2, pPAB19-3, and pPAB19-4, isolated from Salmonella and Escherichia coli clinical strains from hospitals in Argentina, were completely sequenced. These plasmids include the qnrB19 gene and are 2,699, 3,082, 2,989, and 2,702 nucleotides long, respectively, and they share extensive homology among themselves and with other previously described small qnrB19-harboring plasmids. The genetic environment of qnrB19 in all four plasmids is identical to that in these other plasmids and in transposons such as Tn2012, Tn5387, and Tn5387-like. Nucleotide sequence comparisons among these and previously described plasmids showed a variable region characterized by being flanked by an oriT locus and a Xer recombination site. We propose that this arrangement could play a role in the evolution of plasmids and present a model for DNA swapping between plasmid molecules mediated by site-specific recombination events at oriT and a Xer target site.
dc.formatpdf
dc.languageen
dc.publisherAmerican Society for Microbiology
dc.relationAntimicrobial agents and chemotherapy
dc.rightsopen
dc.sourceAntimicrobial Agents and Chemotherapy 2012; 56(4):1821-1827
dc.subjectEscherichia coli
dc.subjectSalmonella
dc.subjectPlásmidos
dc.titleSmall plasmids harboring qnrB19: a model for plasmid evolution mediated by site-specific recombination at oriT and Xer sites
dc.typeArtículo


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