| dc.creator | Irala Parra, Juan Gabriel | |
| dc.creator | Espínola, Emilio E | |
| dc.creator | Amarilla, Alberto A | |
| dc.creator | Stupka, Juan | |
| dc.creator | Martínez, Magali | |
| dc.creator | Zunini, Marta | |
| dc.creator | Galeano, Maria E | |
| dc.creator | Gomes, Karina | |
| dc.creator | Russomando, Graciela | |
| dc.creator | Arbiza, Juan | |
| dc.date | 2020-11-24T16:46:22Z | |
| dc.date | 2020-11-24T16:46:22Z | |
| dc.date | 2007-10 | |
| dc.date.accessioned | 2023-08-29T20:07:13Z | |
| dc.date.available | 2023-08-29T20:07:13Z | |
| dc.identifier | 1386-6532 | |
| dc.identifier | http://sgc.anlis.gob.ar/handle/123456789/1720 | |
| dc.identifier | 10.1016/j.jcv.2007.07.006 | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8519542 | |
| dc.description | Fil: Parra, Gabriel I. Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud. Departamento de Biología Molecular; Paraguay. | |
| dc.description | Fil: Espínola, Emilio E. Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud. Departamento de Biología Molecular; Paraguay. | |
| dc.description | Fil: Amarilla, Alberto A. Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud. Departamento de Biología Molecular; Paraguay. | |
| dc.description | Fil: Stupka, Juan. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | |
| dc.description | Fil: Martínez, Magaly. Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud. Departamento de Biología Molecular; Paraguay. | |
| dc.description | Fil: Zunini, Marta. Hospital Regional de Ciudad del Este; Paraguay. | |
| dc.description | Fil: Galeano, Maria E. Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud. Departamento de Biología Molecular; Paraguay. | |
| dc.description | Fil: Gomes, Karina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina. | |
| dc.description | Fil: Russomando, Graciela. Universidad Nacional de Asunción. Instituto de Investigaciones en Ciencias de la Salud. Departamento de Biología Molecular; Paraguay. | |
| dc.description | Fil: Arbiza, Juan. Universidad de la República. Facultad de Ciencias. Sección Virología; Uruguay. | |
| dc.description | Background: Group A rotaviruses are the main cause of severe gastroenteritis in children worldwide.
Objectives: To survey human rotavirus strains circulating in Paraguay.
Study design: One hundred ninety-six rotavirus-positive fecal samples collected from children up to 5 years old, from 2002 to 2005, were characterized.
Results: The most common G genotype detected was G9 (36.2%), followed by G1 (34.2%), G2 (11.7%) and G4 (8.7%). Changes in the G genotype frequency were observed from year to year. The G4 genotype was predominant in 2002; G1 in 2003; and G9 from 2004 to 2005. Sequence and phylogenetic analysis of the VP7 gene from Paraguayan G1 strains suggested that the high frequency of G1 in 2003 could be due to the introduction of an atypical sub-lineage. In addition, there were amino acid changes in the variable/antigenic regions of the VP7 gene from G4 and G9 strains detected in different years.
Conclusions: This study further indicates that antigenic pressure can drive the evolution of rotaviruses, and also suggests that a vaccine that protects against the most prevalent strains and its variants, will be necessary to elicit a protective immune response against the range of rotavirus types currently circulating in Paraguay. | |
| dc.language | en | |
| dc.publisher | Elsevier | |
| dc.publisher | Pan American Society for Clinical Virology | |
| dc.publisher | European Society for Clinical Virology | |
| dc.relation | #PLACEHOLDER_PARENT_METADATA_VALUE# | |
| dc.relation | datasets | |
| dc.relation | Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology | |
| dc.rights | none | |
| dc.source | Journal of Clinical Virology 2007; 40(2):135-141 | |
| dc.subject | Secuencia de Aminoácidos | |
| dc.subject | Antígenos Virales | |
| dc.subject | Proteínas de la Cápside | |
| dc.subject | Preescolar | |
| dc.subject | Diarrea | |
| dc.subject | Heces | |
| dc.subject | Variación Genética | |
| dc.subject | Humanos | |
| dc.subject | Lactante | |
| dc.subject | Datos de Secuencia Molecular | |
| dc.subject | Paraguay | |
| dc.subject | Filogenia | |
| dc.subject | Rotavirus | |
| dc.subject | Infecciones por Rotavirus | |
| dc.subject | Vigilancia de Guardia | |
| dc.subject | Alineación de Secuencia | |
| dc.subject | Epidemiología Molecular | |
| dc.title | Diversity of group A rotavirus strains circulating in Paraguay from 2002 to 2005: detection of an atypical G1 in South America | |
| dc.type | Artículo | |
