Distribution of human papillomavirus genotypes in women with cervical alterations from north Argentina

dc.creatorDeluca, G D
dc.creatorMarin, H M
dc.creatorBlanco, N S
dc.creatorBasiletti, J A
dc.creatorGonzález, J V
dc.creatorMerino, A L
dc.creatorPicconi, María Alejandra
dc.date2020-11-24T16:47:32Z
dc.date2020-11-24T16:47:32Z
dc.date2013-04
dc.date.accessioned2023-08-29T20:07:12Z
dc.date.available2023-08-29T20:07:12Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1724
dc.identifier10.4103/0255-0857.115228
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519536
dc.descriptionFil: Deluca, G. D. Northeast National University. Faculty of Medicine. Department of Clinical Microbiology. Laboratory of Molecular Application; Argentina.
dc.descriptionFil: Marin, H. M. Northeast National University. Institute of Regional Medicine. Department of Virology. Laboratory of Molecular Biology; Argentina.
dc.descriptionFil: Blanco, N. S. Northeast National University. Faculty of Medicine. Department of Clinical Microbiology. Laboratory of Molecular Application; Argentina.
dc.descriptionFil: Basiletti, J. A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: González, J. V. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Merino, A. L. Northeast National University. Faculty of Medicine. Department of Clinical Microbiology. Laboratory of Molecular Application; Argentina.
dc.descriptionFil: Picconi, M. A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionBackground: Cervical cancer remains a major public health problem in northern Argentina, showing the highest mortality rate in the country (approximately 22 cases/100000 women). Objective: The aim of this study was to provide epidemiological data on the prevalence and type distribution of human papillomavirus (HPV) in women with pre-neoplastic lesions before the massive introduction of HPV vaccination in the country. Materials and methods: Exfoliated cervical cells were collected to screen for HPV using the widely known MY09/11 PCR, followed by the restriction fragment-length polymorphism (RFLP) technique from a total of 714 women with previously diagnosed atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LG-SIL) and high-grade squamous intraepithelial lesion (HG-SIL). Results: Overall HPV prevalence was 48.2% in ASCUS (24 different HPV types detected), 66.5% in LG-SIL (37 HPV types detected) and 82.6% in HG-SIL (16 HPV types detected). HPV-16 was the most prevalent type among all cases. With respect to multiple HPV infections, 9.6% were observed in ASCUS, 14.3% in LG-SIL and 11.4% in HG-SIL. Conclusion: The major strength of our study is the assessment of a large series of women with cytological alterations in this region. The information attained will be useful as a regional baseline for future epidemiological vigilance, in the context of the national HPV vaccination program.
dc.languageen
dc.publisherMedknow Publications
dc.relation#PLACEHOLDER_PARENT_METADATA_VALUE#
dc.relationdatasets
dc.relationIndian journal of medical microbiology
dc.rightsnone
dc.sourceIndian Journal of Medical Microbiology 2013; 31(2):138-141
dc.subjectAdolescente
dc.subjectAdulto
dc.subjectAnciano
dc.subjectArgentina
dc.subjectADN Viral
dc.subjectGenotipo
dc.subjectHumanos
dc.subjectPersona de Mediana Edad
dc.subjectEpidemiología Molecular
dc.subjectPapillomaviridae
dc.subjectInfecciones por Papillomavirus
dc.subjectReacción en Cadena de la Polimerasa
dc.subjectPolimorfismo de Longitud del Fragmento de Restricción
dc.subjectPrevalencia
dc.subjectNeoplasias del Cuello Uterino
dc.subjectAdulto Joven
dc.titleDistribution of human papillomavirus genotypes in women with cervical alterations from north Argentina
dc.typeArtículo


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