A der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient

dc.creatorColli, Sandra
dc.creatorFurforo, Lilian
dc.creatorRojo Pisarello, Eduardo
dc.creatorMaidana, Marcela
dc.creatorMartín, Carlos
dc.creatorBordone, Javier
dc.creatorSlavutsky, Irma
dc.date2020-11-24T12:48:13Z
dc.date2020-11-24T12:48:13Z
dc.date2016-04
dc.date.accessioned2023-08-29T20:07:08Z
dc.date.available2023-08-29T20:07:08Z
dc.identifier2210-7762
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1701
dc.identifier10.1016/j.cancergen.2016.01.001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519502
dc.descriptionFil: Colli, Sandra. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
dc.descriptionFil: Furforo, Lilian. ANLIS Dr.C.G.Malbrán. Centro Nacional de Genética Médica; Argentina.
dc.descriptionFil: Rojo Pisarello, Eduardo. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.
dc.descriptionFil: Maidana, Marcela. Hospital de Alta Complejidad "Presidente Juan Domingo Perón"; Formosa, Argentina.
dc.descriptionFil: Martín, Carlos. Consultorio de Hematopatología; La Plata, Argentina.
dc.descriptionFil: Bordone, Javier. Consultorio de Hematopatología; La Plata, Argentina.
dc.descriptionFil: Slavutsky, Irma. Academia Nacional de Medicina. Instituto de Medicina Experimental. Laboratorio de Genética de Neoplasias Linfoides; Argentina.
dc.descriptionTranslocation t(4;11)(q21;p15) is a rare recurrent change associated to T-cell acute leukemia. In most cases, this alteration appears as the only abnormality or as part of a simple karyotype. In this report, we present the first case of T acute lymphoblastic leukemia/lymphoma (T-ALL/LBL) with the unbalanced translocation der(11)t(4;11)(q21;p15) as part of a very complex karyotype with multiple chromosome abnormalities, most of them not previously described in the literature. FISH (fluorescence in situ hybridization) and spectral karyotype (HiSKY) analysis confirmed the presence of complex alterations. The patient, a 16-year-old male, showed poor response to treatment and short survival (11 months). A detailed review of previously reported cases with t(4;11)(q21;p15) is also provided. The description of this type of alterations may contribute to the identification of new molecular mechanism associated to neoplastic development.
dc.formatpdf
dc.languageen
dc.relationCancer genetics
dc.rightsopen
dc.subjectHibridación Fluorescente in Situ
dc.subjectLeucemia-Linfoma Linfoblástico de Células T Precursoras
dc.subjectCitogenética
dc.titleA der(11)t(4;11)(q21;p15) in a T-ALL/LBL patient
dc.typeArtículo


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