Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings

dc.creatorFeasey, Nicholas A
dc.creatorHadfield, James
dc.creatorKeddy, Karen H
dc.creatorDallman, Timothy J
dc.creatorJacobs, Jan
dc.creatorDeng, Xiangyu
dc.creatorWigley, Paul
dc.creatorBarquist, Lars
dc.creatorLangridge, Gemma C
dc.creatorFeltwell, Theresa
dc.creatorHarris, Simon R
dc.creatorMather, Alison E
dc.creatorFookes, Maria
dc.creatorAslett, Martin
dc.creatorMsefula, Chisomo
dc.creatorKariuki, Samuel
dc.creatorMaclennan, Calman A
dc.creatorOnsare, Robert S
dc.creatorWeill, François-Xavier
dc.creatorLe Hello, Simon
dc.creatorSmith, Anthony M
dc.creatorMcClelland, Michael
dc.creatorDesai, Prerak
dc.creatorParry, Christopher M
dc.creatorCheesbrough, John
dc.creatorFrench, Neil
dc.creatorCampos, Josefina
dc.creatorChabalgoity, Jose A
dc.creatorBetancor, Laura
dc.creatorHopkins, Katie L
dc.creatorNair, Satheesh
dc.creatorHumphrey, Tom J
dc.creatorLunguya, Octavie
dc.creatorCogan, Tristan A
dc.creatorTapia, Milagritos D
dc.creatorSow, Samba O
dc.creatorTennant, Sharon M.
dc.creatorBornstein, Kristin
dc.creatorLevine, Myron M
dc.creatorLacharme-Lora, Lizeth
dc.creatorEverett, Dean B
dc.creatorKingsley, Robert A
dc.creatorParkhill, Julian
dc.creatorHeyderman, Robert S
dc.creatorDougan, Gordon
dc.creatorGordon, Melita A
dc.creatorThomson, Nicholas R
dc.date2020-11-20T16:42:45Z
dc.date2020-11-20T16:42:45Z
dc.date2016-10
dc.date.accessioned2023-08-29T20:07:07Z
dc.date.available2023-08-29T20:07:07Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1695
dc.identifier10.1038/ng.3644
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519494
dc.descriptionFil: Feasey, Nicholas A. Liverpool School of Tropical Medicine; Reino Unido.
dc.descriptionFil: Hadfield, James. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Keddy, Karen H. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica.
dc.descriptionFil: Dallman, Timothy J. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido.
dc.descriptionFil: Jacobs, Jan. Institute of Tropical Medicine; Bélgica.
dc.descriptionFil: Deng, Xiangyu. University of Georgia. Center for Food Safety, Department of Food Science and Technology; Estados Unidos.
dc.descriptionFil: Wigley, Paul. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
dc.descriptionFil: Barquist, Lars. University of Würzburg. Institute for Molecular Infection Biology; Alemania.
dc.descriptionFil: Langridge, Gemma C. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Feltwell, Theresa. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Harris, Simon R. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Mather, Alison E. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Fookes, Maria. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Aslett, Martin. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Msefula, Chisomo. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui.
dc.descriptionFil: Kariuki, Samuel. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia.
dc.descriptionFil: Maclennan, Calman A. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Onsare, Robert S. Kenya Medical Research Institute. Centre for Microbiology Research; Kenia.
dc.descriptionFil: Weill, François-Xavier. Institut Pasteur; Francia.
dc.descriptionFil: Le Hello, Simon. Institut Pasteur; Francia.
dc.descriptionFil: Smith. Anthony M. National Institute for Communicable Diseases. Centre for Enteric Diseases; Sudáfrica.
dc.descriptionFil: McClelland, Michael. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos.
dc.descriptionFil: Desai, Prerak. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos.
dc.descriptionFil: Parry, Christopher M. University of California. Department of Microbiology and Molecular Genetics; Estados Unidos.
dc.descriptionFil: Cheesbrough, John. University of Liverpool. Department of Epidemiology and Population Health; Reino Unido.
dc.descriptionFil: French, Neil. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
dc.descriptionFil: Campos, Josefina. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas.
dc.descriptionFil: Chabalgoity, Jose A. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay.
dc.descriptionFil: Betancor, Laura. Universidad de la República. Facultad de Medicina. Instituto de Higiene; Uruguay.
dc.descriptionFil: Hopkins, Katie L. Public Health England. Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit; Reino Unido.
dc.descriptionFil: Nair, Satheesh. Public Health England. Gastrointestinal Bacteria Reference Unit; Reino Unido.
dc.descriptionFil: Humphrey, Tom J. Swansea University. Swansea Medical School; Reino Unido.
dc.descriptionFil: Lunguya, Octavie. National Institute of Biomedical Research, República Democrática del Congo.
dc.descriptionFil: Cogan, Tristan A. University of Bristol. School of Veterinary Sciences; Reino Unido.
dc.descriptionFil: Tapia, Milagritos D. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
dc.descriptionFil: Sow, Samba O. Centre pour le Développement des Vaccins, Malí.
dc.descriptionFil: Tennant, Sharon M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
dc.descriptionFil: Bornstein, Kristin. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
dc.descriptionFil: Levine, Myron M. University of Maryland. School of Medicine. Center for Vaccine Development; Estados Unidos.
dc.descriptionFil: Lacharme-Lora, Lizeth. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
dc.descriptionFil: Everett, Dean B. University of Liverpool. Institute of Infection and Global Health; Reino Unido.
dc.descriptionFil: Kingsley, Robert A. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Parkhill, Julian. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Heyderman, Robert S. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui.
dc.descriptionFil: Dougan, Gordon. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionFil: Gordon, Melita A. University of Malawi. College of Medicine. Malawi Liverpool Wellcome Trust Clinical Research Programme; Malaui.
dc.descriptionFil: Thomson, Nicholas R. Wellcome Trust Sanger Institute; Reino Unido.
dc.descriptionAn epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
dc.formatpdf
dc.languageen
dc.publisherNature Research
dc.relationNature genetics
dc.rightsopen
dc.sourceNature Genetics 2016; 48(10):1211–1217
dc.subjectAdaptación Biológica
dc.subjectÁfrica del Sur del Sahara
dc.subjectAnimales
dc.subjectPollos
dc.subjectEnterocolitis
dc.subjectEpidemias
dc.subjectGenoma Bacteriano
dc.subjectHumanos
dc.subjectRenta
dc.subjectPlásmidos
dc.subjectEnfermedades de las Aves de Corral
dc.subjectInfecciones por Salmonella
dc.subjectAnálisis de Secuencia de ADN
dc.subjectSalmonella enteritidis
dc.titleDistinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings
dc.typeArtículo


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