Distinct monocyte subset phenotypes in patients with different clinical forms of chronic Chagas disease and seronegative dilated cardiomyopathy

dc.creatorPérez-Mazliah, Damián E
dc.creatorCastro Eiro, Melisa D
dc.creatorAlvarez, María Gabriela
dc.creatorLococo, Bruno
dc.creatorBertocchi, Graciela
dc.creatorCesar, Gonzalo
dc.creatorNatale, María Ailén
dc.creatorAlbareda, María Cecilia
dc.creatorViotti, Rodolfo
dc.creatorLaucella, Susana A.
dc.date2020-11-19T21:51:47Z
dc.date2020-11-19T21:51:47Z
dc.date2018-10-22
dc.date.accessioned2023-08-29T20:07:06Z
dc.date.available2023-08-29T20:07:06Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1686
dc.identifier10.1371/journal.pntd.0006887
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519485
dc.descriptionFil: Pérez-Mazliah, Damián E. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Castro Eiro, Melisa D. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Álvarez, María Gabriela. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: Lococo, Bruno. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: Bertocchi, Graciela. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: César, Gonzalo. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Natale, María A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Albareda, María C. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionFil: Viotti, Rodolfo. Hospital Interzonal General de Agudos Eva Perón; Argentina.
dc.descriptionFil: Laucella, Susana A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina.
dc.descriptionChronic infection with Trypanosoma cruzi leads to a constant stimulation of the host immune system. Monocytes, which are recruited in response to inflammatory signals, are divided into classical CD14hiCD16-, non-classical CD14loCD16+ and intermediate CD14hiCD16+ subsets. In this study, we evaluated the frequencies of monocyte subsets in the different clinical stages of chronic Chagas disease in comparison with the monocyte profile of seronegative heart failure subjects and seronegative healthy controls. The effect of the anti-parasite drug therapy benznidazole on monocyte subsets was also explored.
dc.formatpdf
dc.languageen
dc.relationPLoS neglected tropical diseases
dc.rightsopen
dc.sourcePLoS Neglected Tropical Diseases 2018; 12(10):1-16
dc.subjectAdulto
dc.subjectAnciano
dc.subjectAnticuerpos Antiprotozoarios
dc.subjectCardiomiopatía Dilatada
dc.subjectEnfermedad de Chagas
dc.subjectCitometría de Flujo
dc.subjectProteínas Ligadas a GPI
dc.subjectHumanos
dc.subjectInmunofenotipificación
dc.subjectReceptores de Lipopolisacáridos
dc.subjectPersona de Mediana Edad
dc.subjectMonocitos
dc.subjectReceptores de IgG
dc.subjectTrypanosoma cruzi
dc.subjectAdulto Joven
dc.subjectFenotipo
dc.titleDistinct monocyte subset phenotypes in patients with different clinical forms of chronic Chagas disease and seronegative dilated cardiomyopathy
dc.typeArtículo


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