Screening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections

dc.creatorAbascal, Estefanía
dc.creatorHerranz, Marta
dc.creatorAcosta, Fermín
dc.creatorAgapito, Juan
dc.creatorCabibbe, Andrea M
dc.creatorMonteserin, Johana
dc.creatorRuiz Serrano, María Jesús
dc.creatorGijón, Paloma
dc.creatorFernández-González, Francisco
dc.creatorLozano, Nuria
dc.creatorChiner-Oms, Álvaro
dc.creatorCáceres, Tatiana
dc.creatorPintado, Pilar Gómez
dc.creatorAcín, Enrique
dc.creatorValencia, Eddy
dc.creatorMuñoz, Patricia
dc.creatorComas, Iñaki
dc.creatorCirillo, Daniela M
dc.creatorRitacco, Viviana
dc.creatorGotuzzo, Eduardo
dc.creatorGarcia de Viedma, Dario
dc.date2020-11-24T16:50:40Z
dc.date2020-11-24T16:50:40Z
dc.date2020
dc.date.accessioned2023-08-29T20:07:04Z
dc.date.available2023-08-29T20:07:04Z
dc.identifier2045-2322
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1727
dc.identifier10.1038/s41598-020-59373-w
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519469
dc.descriptionFil: Abascal, Estefanía. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
dc.descriptionFil: Herranz, Marta. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
dc.descriptionFil: Acosta, Fermín. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
dc.descriptionFil: Agapito, Juan. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
dc.descriptionFil: Cabibbe, Andrea M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.
dc.descriptionFil: Monteserín, Johana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
dc.descriptionFil: Ruiz Serrano, María Jesús. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionFil: Gijón, Paloma. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionFil: Fernández-González, Francisco. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionFil: Lozano, Nuria. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionFil: Chiner-Oms, Álvaro. Unidad Mixta Genómica y Salud, Centro Superior de Investigación en Salud Pública (FISABIO)-Universitat de València; España.
dc.descriptionFil: Cáceres, Tatiana. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
dc.descriptionFil: Gómez Pintado, Pilar. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.
dc.descriptionFil: Acín, Enrique. General Subdirection of Penitentiary Health - Penitentiary Institutions - Ministry of Interior of Spain; España.
dc.descriptionFil: Muñoz, Patricia. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España
dc.descriptionFil: Comas, Iñaki. Instituto de Biomedicina de Valencia (IBV) Consejo Superior de Investigaciones Científicas (CSIC); España.
dc.descriptionFil: Cirillo, Daniela M. Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milan; Italia.
dc.descriptionFil: Ritacco, Viviana. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Epidemiología; Argentina.
dc.descriptionFil: Gotuzzo, Eduardo. TB Research Unit, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima; Peru.
dc.descriptionFil: García de Viedma, Dario. Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid; España.
dc.descriptionIt is relevant to evaluate MDR-tuberculosis in prisons and its impact on the global epidemiology of this disease. However, systematic molecular epidemiology programs in prisons are lacking. A health-screening program performed on arrival for inmates transferred from Peruvian prisons to Spain led to the diagnosis of five MDR-TB cases from one of the biggest prisons in Latin America. They grouped into two MIRU-VNTR-clusters (Callao-1 and Callao-2), suggesting a reservoir of two prevalent MDR strains. A high-rate of overexposure was deduced because one of the five cases was coinfected by a pansusceptible strain. Callao-1 strain was also identified in 2018 in a community case in Spain who had been in the same Peruvian prison in 2002-5. A strain-specific-PCR tailored from WGS data was implemented in Peru, allowing the confirmation that these strains were currently responsible for the majority of the MDR cases in that prison, including a new mixed infection.
dc.formatpdf
dc.languageen
dc.relationScientific reports
dc.rightsopen
dc.sourceScientific reports 2020; 10(1):2704
dc.subjectAntibióticos Antituberculosos
dc.titleScreening of inmates transferred to Spain reveals a Peruvian prison as a reservoir of persistent Mycobacterium tuberculosis MDR strains and mixed infections
dc.typeArtículo


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