Preclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms

dc.creatorSegura, A
dc.creatorde Castillo, M. C.
dc.creatorNúñez, V
dc.creatorYarlequé, A
dc.creatorGonçalves, L R C
dc.creatorVillalta, M
dc.creatorBonilla, C
dc.creatorHerrera, M
dc.creatorVargas, M.
dc.creatorFernández, M
dc.creatorYano, M Y
dc.creatorAraújo, H P
dc.creatorBoller, M A A
dc.creatorLeón, P
dc.creatorTintaya, B
dc.creatorSano-Martins, I S
dc.creatorGómez, A
dc.creatorFernández, G P
dc.creatorGeoghegan, Patricia A.
dc.creatorHigashi, H G
dc.creatorLeón, G
dc.creatorGutiérrez, J M
dc.date2020-09-16T20:12:34Z
dc.date2020-09-16T20:12:34Z
dc.date2010-11
dc.date.accessioned2023-08-29T20:06:58Z
dc.date.available2023-08-29T20:06:58Z
dc.identifier0041-0101
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1649
dc.identifierhttps://doi.org/10.1016/j.toxicon.2010.07.001
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519417
dc.descriptionFil: Segura, A. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.
dc.descriptionFil: de Castillo, M. C. INVIMA, Bogotá; Colombia.
dc.descriptionFil: Núñez, V. Universidad de Antioquia, Medellín; Colombia.
dc.descriptionFil: Yarlequé, A. Universidad Nacional Mayor de San Marcos, Lima; Perú.
dc.descriptionFil: Gonçalves, L. R. C. Instituto Butantan, São Paulo; Brasil.
dc.descriptionFil: Villalta, M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.
dc.descriptionFil: Bonilla, C. Instituto Nacional de Salud, Lima; Perú.
dc.descriptionFil: Herrera, M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.
dc.descriptionFil: Vargas, M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.
dc.descriptionFil: Fernández, M. Universidad de Antioquia, Medellín; Colombia.
dc.descriptionFil: Yano, M. Y. Instituto Butantan, São Paulo; Brasil.
dc.descriptionFil: Araújo, H. P. INCQS, Fiocruz, Rio de Janeiro; Brasil.
dc.descriptionFil: Boller, M. A. A. INCQS, Fiocruz, Rio de Janeiro; Brasil.
dc.descriptionFil: León, P. INVIMA, Bogotá; Colombia.
dc.descriptionFil: Tintaya, B. Instituto Nacional de Salud, Lima; Perú.
dc.descriptionFil: Sano-Martins, I. S. Instituto Butantan, São Paulo; Brasil.
dc.descriptionFil: Gómez, A. Instituto Nacional de Salud, Bogotá; Colombia.
dc.descriptionFil: Fernández, G. P. INLASA, La Paz; Bolivia.
dc.descriptionFil: Geoghegan, Patricia A. ANLIS Dr.C.G.Malbrán. Centro Nacional de Control de Calidad de Biológicos; Argentina.
dc.descriptionFil: Higashi, H. G. Instituto Butantan, São Paulo; Brasil.
dc.descriptionFil: León, G. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.
dc.descriptionFil: Gutiérrez, J. M. Universidad de Costa Rica. Instituto Clodomiro Picado; Costa Rica.
dc.descriptionSpecies of the genus Bothrops induce the vast majority of snakebite envenomings in Latin America. A preclinical study was performed in the context of a regional network of public laboratories involved in the production, quality control and development of antivenoms in Latin America. The ability of seven polyspecific antivenoms, produced in Argentina, Brazil, Peru, Bolivia, Colombia and Costa Rica, to neutralize lethal, hemorrhagic, coagulant, defibrinogenating and myotoxic activities of the venoms of Bothrops neuwiedi (diporus) (Argentina), Bothrops jararaca (Brazil), B. neuwiedi (mattogrossensis) (Bolivia), Bothrops atrox (Peru and Colombia) and Bothrops asper (Costa Rica) was assessed using standard laboratory tests. Despite differences in the venom mixtures used in the immunization of animals for the production of these antivenoms, a pattern of extensive cross-neutralization was observed between these antivenoms and all the venoms tested, with quantitative differences in the values of effective doses. This study reveals the capacity of these antivenoms to neutralize, in preclinical tests, homologous and heterologous Bothrops venoms in Central and South America, and also highlight quantitative differences in the values of Median Effective Doses (ED50s) between the various antivenoms.
dc.formatpdf
dc.languageen
dc.relationToxicon : official journal of the International Society on Toxinology
dc.rightsnone
dc.sourceToxicon 2010;56(6):908-989
dc.subjectMordeduras de Serpientes
dc.subjectAmérica Latina
dc.subjectArgentina
dc.subjectBrasil
dc.subjectPerú
dc.subjectBolivia
dc.subjectCosta Rica
dc.subjectAntivenenos
dc.titlePreclinical assessment of the neutralizing capacity of antivenoms produced in six Latin American countries against medically-relevant Bothrops snake venoms
dc.typeArtículo


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