Dexamethasone prevents motor deficits and neurovascular damage produced by shiga toxin 2 and lipopolysaccharide in the mouse striatum

dc.creatorPinto, Alipio
dc.creatorCangelosi, Adriana
dc.creatorGeoghegan, Patricia A.
dc.creatorGoldstein, Jorge
dc.date2020-09-16T00:55:25Z
dc.date2020-09-16T00:55:25Z
dc.date2017
dc.date.accessioned2023-08-29T20:06:57Z
dc.date.available2023-08-29T20:06:57Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1645
dc.identifier10.1016/j.neuroscience.2016.12.036
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519410
dc.descriptionShiga toxin 2 (Stx2) from enterohemorrhagic Escherichia coli (EHEC) causes bloody diarrhea and Hemolytic Uremic Syndrome (HUS) that may derive to fatal neurological outcomes. Neurological abnormalities in the striatum are frequently observed in affected patients and in studies with animal models while motor disorders are usually associated with pyramidal and extra pyramidal systems. A translational murine model of encephalopathy was employed to demonstrate that systemic administration of a sublethal dose of Stx2 damaged the striatal microvasculature and astrocytes, increase the blood brain barrier permeability and caused neuronal degeneration. All these events were aggravated by lipopolysaccharide (LPS). The injury observed in the striatum coincided with locomotor behavioral alterations. The anti-inflammatory Dexamethasone resulted to prevent the observed neurologic and clinical signs, proving to be an effective drug. Therefore, the present work demonstrates that: (i) systemic sub-lethal Stx2 damages the striatal neurovascular unit as it succeeds to pass through the blood brain barrier. (ii) This damage is aggravated by the contribution of LPS which is also produced and secreted by EHEC, and (iii) the observed neurological alterations may be prevented by an anti-inflammatory treatment.
dc.languageen
dc.relationNeuroscience
dc.rightsnone
dc.subjectBarrera Hematoencefálica
dc.subjectSíndrome Hemolítico-Urémico
dc.subjectEncefalopatía
dc.subjectInflamación
dc.subjectBarrera Hematoencefálica
dc.titleDexamethasone prevents motor deficits and neurovascular damage produced by shiga toxin 2 and lipopolysaccharide in the mouse striatum
dc.typeArtículo


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