Frequency and geographical distribution of genotypes and mating types of Cryptococcus neoformans and Cryptococcus gattii species complexes in Argentina

dc.creatorTaverna, Constanza Giselle
dc.creatorBosco-Borgeat, María Eugenia
dc.creatorMazza, Mariana
dc.creatorVivot, Matias Ezequiel
dc.creatorDavel, Graciela Odelsia
dc.creatorCanteros, Cristina
dc.date2020-01-22T12:52:11Z
dc.date2020-01-22T12:52:11Z
dc.date2020-01-13
dc.date.accessioned2023-08-29T20:06:42Z
dc.date.available2023-08-29T20:06:42Z
dc.identifier0325-7541
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1515
dc.identifierhttps://www.sciencedirect.com/science/article/pii/S0325754119300884
dc.identifier10.1016/j.ram.2019.07.005
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519265
dc.descriptionFil: Taverna, CG. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Bosco-Borgeat, ME. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Mazza, M. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Vivot, ME. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionFil: Davel, Graciela Odelsia. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas. Departamento de Micología; Argentina.
dc.descriptionFil: Canteros, Cristina Elena. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Enfermedades Infecciosas; Argentina.
dc.descriptionThe aim of this work was to know the frequency and geographical distribution of genotypes and mating types of Cryptococcus neoformans and Cryptococcus gattii species complexes isolated from human infections in Argentina during the period from April 2009 to April 2011. A multicenter study was conducted, in which 372 isolates were obtained from 61 laboratories throughout the country. Of those, 98.8% of the isolates belonged to the C. neoformans species complex and 1.1% to the C. gattii species complex. Genotype VNI (MATα) was the most frequently isolated (n=326, 87.6%), followed by VNII (MATα) (n=22, 5.9%), the recently described VNII-VNIV (aADα) hybrid (n=14, 3.8%), VNIV (MATα) (n=4, 1.1%), VNIII (αADa) hybrid (n=1, 0.3%), and VNIII (αADα) hybrid (n=1, 0.3%). The Argentine Central region showed the greatest number of cases and genotype diversity. Interestingly, a relative high frequency was observed in genotype VNII (MATα) in the Cuyo, Northeast and Northwest regions and, also in VNII-VNIV (aADα) hybrids in the Northwest region. C. gattii species complex was isolated at a low rate; 3 VGI (MATα) and 1 VGII (MATα) isolates were obtained from the Northwest and Central regions. In conclusion, this study shows that genotype frequencies seem to vary among regions in Argentina and reveals a relatively high frequency of rare hybrids in the Northwest region. Further regional clinical and environmental studies may help to elucidate if those variations in frequencies are associated with the existence of regional ecological niches or any other regional factors.
dc.descriptionGenotipificación; Genotyping; Hybrids; Híbridos; Mating type; Tipo sexual
dc.formatpdf
dc.languageen
dc.relationRevista Argentina de microbiologia
dc.rightsopen
dc.subjectCriptococosis
dc.subjectCryptococcus
dc.subjectCryptococcus neoformans
dc.subjectCryptococcus gattii
dc.subjectPerfil Genético
dc.subjectGenotipo
dc.subjectArgentina
dc.titleFrequency and geographical distribution of genotypes and mating types of Cryptococcus neoformans and Cryptococcus gattii species complexes in Argentina
dc.typeArtículo


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