| dc.creator | Laucella, Susana A. | |
| dc.creator | Segura, Elsa L. | |
| dc.creator | Riarte, Adelina | |
| dc.creator | Sosa-Estani, Sergio | |
| dc.date | 2019-12-12T20:07:21Z | |
| dc.date | 2019-12-12T20:07:21Z | |
| dc.date | 1999-12 | |
| dc.date.accessioned | 2023-08-29T20:06:39Z | |
| dc.date.available | 2023-08-29T20:06:39Z | |
| dc.identifier | 0009-9104 | |
| dc.identifier | http://sgc.anlis.gob.ar/handle/123456789/1498 | |
| dc.identifier | 10.1046/j.1365-2249.1999.01070.x | |
| dc.identifier.uri | https://repositorioslatinoamericanos.uchile.cl/handle/2250/8519235 | |
| dc.description | Fil: Laucella, Susana A.ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | |
| dc.description | Fil: Segura, E L. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | |
| dc.description | Fil: Riarte, A. ANLIS Dr.C.G.Malbrán. Instituto Nacional de Parasitología; Argentina. | |
| dc.description | Fil: Sosa E. M. de. Centro Nacional de Diagnóstico e Investigación de Endemoepidemias, Ministerio de Salud y Acción Social, Buenos Aires; Argentina. | |
| dc.description | The immune response against Trypanosoma cruzi infection has been associated with both protection and pathogenesis. Central events in host defence system- and immune-mediated damage are tightly regulated by cell adhesion molecules (CAM). Levels of sP-selectin and sVCAM-1 were measured in sera from 41 children with the indeterminate phase of Chagas' disease. Simultaneously, levels of soluble adhesion molecule were also quantified in Chagas' disease children undergoing specific chemotherapy with benznidazole. Levels of sP-selectin and sVCAM-1 were found to be elevated in children with indeterminate Chagas' disease before aetiologic therapy was started. However, a small group of patients showed sP-selectin and sVCAM-1 levels comparable to those of non-infected children. A positive correlation between levels of sVCAM-1 and sP-selectin in sera from Chagas' disease patients was found. There was a significantly greater decrease in the titres of sP-selectin and sVCAM-1 in those children receiving benznidazole therapy compared with those children receiving placebo. Measurement of soluble adhesion molecules revealed differences in the activation of the immune system in children with the indeterminate form of Chagas' disease. The early decrease of sP-selectin and sVCAM-1 levels after anti-parasitic treatment suggests that these molecules might be valuable indicators of effective parasitologic clearance. | |
| dc.format | pdf | |
| dc.language | en | |
| dc.publisher | Wiley | |
| dc.relation | Clinical and experimental immunology | |
| dc.rights | open | |
| dc.source | Clinical and experimental immunology 1999;118(3):423-7. | |
| dc.subject | Trypanosoma cruzi | |
| dc.subject | Enfermedad de Chagas | |
| dc.title | Soluble platelet selectin (sP-selectin) and soluble vascular cell adhesion molecule-1 (sVCAM-1) decrease during therapy with benznidazole in children with indeterminate form of Chagas' disease | |
| dc.type | Artículo | |
