Chronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence

dc.creatorAlbareda, María Cecilia
dc.creatorOlivera, Gabriela Carina
dc.creatorLaucella, Susana A.
dc.creatorAlvarez, María Gabriela
dc.creatorFernandez, Esteban Rodrigo
dc.creatorLococo, Bruno
dc.creatorViotti, Rodolfo
dc.creatorTarleton, Rick L
dc.creatorPostan, Miriam
dc.date2019-12-09T20:36:22Z
dc.date2019-12-09T20:36:22Z
dc.date2009-09-15
dc.date.accessioned2023-08-29T20:06:32Z
dc.date.available2023-08-29T20:06:32Z
dc.identifierhttp://sgc.anlis.gob.ar/handle/123456789/1485
dc.identifier10.4049/jimmunol.0900852
dc.identifier.urihttps://repositorioslatinoamericanos.uchile.cl/handle/2250/8519213
dc.descriptionPreviously we found that the frequency of IFN-gamma-producing CD8(+) T cells specific for Trypanosoma cruzi inversely correlates with disease severity in chronic human Chagas disease along with low levels of IL-2-secreting CD8(+) T cells in all clinical stages. This impairment of the parasite-specific T cell responses was associated with phenotypic features of immune senescence of the CD8(+) T cell compartment. These data prompted us to address the question of whether the CD4(+) T cell compartment also experiences signs of exhaustion. Thus, we performed a functional and phenotypical characterization of T. cruzi-specific and overall CD4(+) T cells in chronically infected subjects with different degrees of cardiac dysfunction. The results show an inverse association between disease severity and the frequency of T. cruzi-specific IFN-gamma-producing CD4(+) T cells. The high expression of CD27 and CD28 with a relative low expression of CD57 found on CD4(+)IFN-gamma(+) T cells suggests that the effector T cell pool in chronic T. cruzi infection includes a high proportion of newly recruited T cells, but a low frequency of long-term memory cells. The total CD4(+) T cell compartment shows signs of senescence and later stages of differentiation associated with more severe stages of the disease. These findings support the hypothesis that long-term T. cruzi infection in humans might exhaust long-lived memory T cells.
dc.languageen
dc.relationJournal of immunology (Baltimore, Md. : 1950)
dc.rightsopen
dc.titleChronic human infection with Trypanosoma cruzi drives CD4+ T cells to immune senescence
dc.typeArtículo


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